Danazol binds to progesterone receptors and inhibits the growth of human endometrial cancer cells in vitro

Hiromasa Ikegami, H Ikegami, N Terakawa, Naoki Terakawa, Ikuya Shimizu, I Shimizu, Hideo Kanō, H Kano, Yoshiaki Tanaka, Y Tanaka, T Aono, Toshihiro Aono, Osamu Tanizawa, O. Tanizawa, K Matsumoto, Keishi Matsumoto
American journal of obstetrics and gynecology · 1986 · vol. 155(4) , pp. 857–861 · doi:10.1016/s0002-9378(86)80039-4 · PMID:3766641 · W2013015441
Lab / animal OA: closed CC0 ⤵ 16 in-corpus citations
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Danazol binds to progesterone receptors and inhibits the growth of human endometrial cancer cells in vitro.

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Abstract

Based on our recent findings that danazol, an isoxazol derivative of ethinyltestosterone, has a profound growth-inhibitory effect on an established human endometrial adenocarcinoma cell line, the effects of danazol on cancer cells from human endometrial adenocarcinomas obtained by hysterectomy were investigated in the present study. Of the 22 uterine adenocarcinomas, estrogen, progesterone, and androgen receptors were found in 12, 14, and 4 tumors, respectively. Competitive binding studies showed that danazol specifically binds to progesterone and androgen receptors but not to estrogen receptors. Of the five cancer cells from five patients succeeded in primary cell culture, a marked inhibition of cell growth was demonstrated by addition of danazol in two cancer cells having progesterone but not androgen receptors. However, danazol did not affect the growth of the remaining three cancer cells lacking progesterone receptors. These results strongly suggest that danazol has a significant growth-inhibitory effect on human endometrial adenocarcinoma cells, possibly through progesterone receptors in the cells.

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MeSH descriptors

Adenocarcinoma Danazol Pregnadienes Receptors, Progesterone Uterine Neoplasms Adenocarcinoma Adenocarcinoma Adult Binding, Competitive Cell Division Cell Division Cells, Cultured Danazol Danazol Female Humans Middle Aged Pregnadienes Receptors, Androgen Receptors, Androgen

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