Lipidomic Alterations and PPARα Activation Induced by Resveratrol Lead to Reduction in Lesion Size in Endometriosis Models

Zhengyun Chen, Chunyan Wang, Cuicui Lin, Lifeng Zhang, Huimei Zheng, Yong Zhou, Xiaoyong Li, Chen Li, Xinmei Zhang, Xiaohang Yang, Min‐Xin Guan, Yongmei Xi
Oxidative medicine and cellular longevity · 2021 · vol. 2021(1) , pp. 9979953 · doi:10.1155/2021/9979953 · PMID:34552688 · W3201446103
article OA: hybrid CC0 ⤵ 16 in-corpus citations
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Resveratrol treatment reduced lesion size in endometriosis models by altering lipid profiles, decreasing HEcESC proliferation and invasiveness, increasing apoptosis, and activating PPARα.

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Abstract

Endometriosis is an estrogen‐dependent chronic inflammatory disease that affects approximately 10% of women of reproductive age and up to 50% of women with infertility. The heterogeneity of the disease makes accurate diagnosis and treatment a clinical challenge. In this study, we generated two models of endometriosis: the first in rats and the second using human ectopic endometrial stromal cells (HEcESCs) derived from the lesion tissues of endometriosis patients. We then applied resveratrol to assess its therapeutic potential. Resveratrol intervention had significant efficacy to attenuate lesion size and to rectify aberrant lipid profiles of model rats. Lipidomic analysis revealed significant lipidomic alterations, including notable increases of sphingolipids and decreases of both glycerolipids and most phospholipids. Upon resveratrol application, both proliferation capacity and invasiveness parameters decreased, and the early apoptosis proportion increased for HEcESCs. The activation of PPAR α was also noted as a factor potentially contributing to recovery from endometriosis in both models. Our study provides valuable insight into the mechanisms of resveratrol in endometriosis and therefore strengthens the potential for optimizing resveratrol treatment for this disease.

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Endometriosis Endometrium Lipid Metabolism PPAR alpha Resveratrol Animals Antioxidants Antioxidants Apoptosis Disease Models, Animal Endometriosis Endometriosis Endometriosis Endometrium Endometrium Female Gene Expression Profiling Humans Lipid Metabolism Lipidomics

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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