Update on endometriosis pathogenesis

A Czyźyk, Adam Czyzyk, Agnieszka Podfigurna, Anna Szeliga, Blazej Meczekalski, Błażej Męczekalski
Minerva ginecologica · 2017 · vol. 69(5) , pp. 447–461 · doi:10.23736/s0026-4784.17.04048-5 · PMID:28271702 · W2606025924
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Abstract

Endometriosis is a chronic, inflammatory, condition of high incidence and serious reproductive and general health consequences. Understanding the pathogenesis of endometriosis is crucial for proper diagnostic and ordering the most effective treatment. Even though there is a large body of data regarding this pathology our understanding of the pathogenesis of this disease remains incomplete. The aim of this review is to summarize contemporary data regarding pathogenesis of endometriosis. Current data regarding endometrial origin, metaplastic and Mullerian embryonic rests theory will be reviewed here. Also genetic, epigenetic, environmental factors and immunological dysfunction role in endometriosis will be summarized. To conclude, a lot of effort must be put to integrate the abundant data from genetic, epigenetic and immunological studies to propose one coherent theory for the pathogenesis of endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Epigenesis, Genetic Mullerian Ducts Endometriosis Endometriosis Endometriosis Female Humans Risk Factors

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