Effects ofLactobacillus gasseriOLL2809 on the Induced Endometriosis in Rats
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Lactobacillus gasseri OLL2809 administration significantly reduced induced endometriosis lesion volume in rats compared to controls, with complete healing observed in some subjects.
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Abstract
We have reported an inhibitory effect of Lactobacillus gasseri OLL2809 (OLL2809) on the growth of mouse endometrial tissue in the abdominal cavity. The present study aimed to investigate the efficacy of Lactobacillus gasseri OLL2809 (OLL2809) on pre-existing endometriosis implanted on the abdominal wall in diestrus Wistar-Imamichi female rats. One week after implantation, the volume of the endometrial tissue was measured after laparotomy. OLL2809 and dienogest were administered for 4 weeks. OLL2809 significantly enhanced the decrease in the volume (p<0.01) as compared with control. Complete healing was observed in two of nine rats, but in none of the control group. Dienogest did not show significant efficacy. These findings suggest that OLL2809 is useful not only in therapy of pre-existing endometriosis but also in the prevention of the growth of endometrial tissue.
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- The Multifactorial Pathogenesis of Endometriosis: A Narrative Review Integrating Hormonal, Immune, and Microbiome Aspects 2025
- Eating for Optimization: Unraveling the Dietary Patterns and Nutritional Strategies in Endometriosis Management 2024
- A large-scale causal analysis of gut microbiota and endometriosis associated infertility: A Mendelian randomization study 2024
- Correlation between dysbiosis of vaginal microecology and endometriosis: A systematic review and meta-analysis 2024
- Endometriosis: Pathogenesis, Diagnosis and Treatment, volume II 2024
- Integration of 16 S rRNA gene sequencing, metabonomics and metagenome analysis to investigate the mechanism of Sparganium stoloniferum-Curcuma phaeocaulis in treating of endometriosis in rats 2024
- Endometriosis, Pain, and Related Psychological Disorders: Unveiling the Interplay among the Microbiome, Inflammation, and Oxidative Stress as a Common Thread 2024
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- The bidirectional relationship between endometriosis and microbiome 2023
- Current Updates on the Role of Microbiome in Endometriosis: A Narrative Review 2023
- Correlations between Gut Microbial Composition, Pathophysiological and Surgical Aspects in Endometriosis: A Review of the Literature 2023
- Microbiota in Irritable Bowel Syndrome and Endometriosis: Birds of a Feather Flock Together—A Review 2023
- The gut microbiota and endometriosis: From pathogenesis to diagnosis and treatment 2022
- Intricate Connections between the Microbiota and Endometriosis 2021
- New Opportunities for Endometrial Health by Modifying Uterine Microbial Composition: Present or Future? 2020
- Pharmacological Characteristics of Lacobacillus gasseri OLL2809 and its Application to the Endometriosis Therapy 2014
Source provenance
- europepmc
- last seen: 2026-06-04T01:30:01.192114+00:00
- openalex
- last seen: 2026-06-04T00:00:01.174412+00:00
- pubmed
- last seen: 2026-05-13T22:18:53.335890+00:00
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