Intercellular Adhesion Molecule-1 and Hepatocyte Growth Factor in Human Endometriosis: Original Investigation and a Review of Literature

T Fukaya, Junichi Sugawara, J Sugawara, Hidemune Yoshida, H Yoshida, T Murakami, Takashi Murakami, A Yajima, Akira Yajima
Gynecologic and obstetric investigation · 1999 · vol. 47(Suppl. 1) , pp. 11–17 · doi:10.1159/000052854 · PMID:10087423 · W2048333918
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study found increased concentrations of soluble ICAM-1 and HGF in women with endometriosis, with ICAM-1 impairing natural killer cell activity and HGF stimulating endometrial cell proliferation and migration.

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Abstract

Defects in the cell-mediated immune system may play a role in the pathogenesis or progression of pelvic endometriosis. Possible mediators include macrophages, interleukins-1 and -6, and tumor necrosis factor-alpha. More recent work points to the involvement of adhesion molecules and growth factors. To clarify the pathogenesis of endometriosis, we compared the characteristics of soluble intercellular adhesion molecule-1 (soluble ICAM-1) and hepatocyte growth factor (HGF) in women with and without endometriosis. We found that, in patients with endometriosis, the concentrations of soluble ICAM-1 in peritoneal fluid increased and interfered with the activity of natural killer cells. We also found that HGF secretion was significantly increased in cultured endometrial stromal cells, and that HGF stimulated the proliferation and migration of, and morphogenic changes in, endometrial epithelial cells. HGF and ICAM-1 play important roles in the initiation and regulation of endometriotic lesions on the microenvironment level. The increased secretion of HGF by eutopic endometrial stromal cells may contribute to the pathogenesis of endometriosis, whereas the increased levels of soluble ICAM-1 may impair natural killer cell activity and accelerate the progression of the disease.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Hepatocyte Growth Factor Intercellular Adhesion Molecule-1 Cell Division Cell Division Cell Movement Cell Movement Cells, Cultured Dose-Response Relationship, Drug Endometriosis Endometriosis Endometrium Endometrium Endometrium Extracellular Space Extracellular Space Female Hepatocyte Growth Factor Hepatocyte Growth Factor Humans

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (26)

Cited by (44)

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