The role of progestins in treating the pain of endometriosis

Eric S Surrey

doi:10.1016/j.jmig.2006.06.008

The role of progestins in treating the pain of endometriosis

Eric S Surrey

Journal of Minimally Invasive Gynecology · 2006 · vol. 13(6) , pp. 528–534 · doi:10.1016/j.jmig.2006.06.008 · PMID:17097575 · W1997243005

review OA: closed CC0 ⤵ 30 in-corpus citations

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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This paper reviews the role of progestins in managing endometriosis-associated pain, exploring their mechanisms of action and clinical efficacy.

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Condition tags

mesh:D004715mesh:D017699endometriosis

MeSH descriptors

Endometriosis Pelvic Pain Progestins Contraceptive Agents, Female Contraceptive Agents, Female Endometriosis Endometriosis Female Gestrinone Gestrinone Hormone Antagonists Hormone Antagonists Humans Injections, Subcutaneous Medroxyprogesterone Acetate Medroxyprogesterone Acetate Mifepristone Mifepristone Pelvic Pain Pelvic Pain

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References (57)

All progestins are not created equal via openalex
Antiprogestin and/or gonadotropin-releasing hormone agonist for endometriosis treatment and bone maintenance: a 1-year primate study via openalex
Antiprogestin and/or gonadotropin-releasing hormone agonist for endometriosis treatment and bone maintenance: a 1-year primate study. via openalex
A randomized double-blind prospective trial of two doses of gestrinone in the treatment of endometriosis via openalex
Clinical, endocrine, and metabolic effects of two doses of gestrinone in treatment of pelvic endometriosis via openalex
Cyproterone acetate versus a continuous monophasic oral contraceptive in the treatment of recurrent pelvic pain after conservative surgery for symptomatic endometriosis via openalex
Depot medroxyprogesterone acetate versus an oral contraceptive combined with very-low-dose danazol for long-term treatment of pelvic pain associated with endometriosis via openalex
Dienogest is as effective as triptorelin in the treatment of endometriosis after laparoscopic surgery: results of a prospective, multicenter, randomized study via openalex
Direct effects of medroxyprogesterone acetate, danazol, and leuprolide acetate on endometrial stromal cell proliferation in vitro via openalex
Effect of norethindrone acetate in the treatment of symptomatic endometriosis. via openalex
Endometriosis [ <i>Abridged</i> ] via openalex
Endometriosis therapy with medroxyprogesterone acetate. via openalex
Endometriosis treated with lynestrenol. via openalex
[Endometriosis treated with Lynestrenol]. via openalex
Evaluation of oral medroxyprogesterone acetate in the treatment of endometriosis. via openalex
Gestrinone versus a gonadotropin-releasing hormone agonist for the treatment of pelvic pain associated with endometriosis: a multicenter, randomized, double-blind study via openalex
Human Endometrium and Endometriotic Tissue Obtained Simultaneously via openalex
Immunohistochemical analysis of estrogen and progesterone receptors in endometriosis: comparison with normal endometrium during the menstrual cycle and the effect of medical therapy via openalex
Impact of gestrinone on the course of asymptomatic endometriosis. via openalex
Lipoprotein changes during treatment of pelvic endometriosis with medroxyprogesterone acetate via openalex
Lipoprotein changes during treatment of pelvic endometriosis with medroxyprogesterone acetate. via openalex
MANAGEMENT OF ENDOMETRIOSIS WITH ORAL MEDROXYPROGESTERONE ACETATE via openalex
Megestrol acetate for treatment of endometriosis. via openalex
Placebo-controlled comparison of danazol and high-dose medroxyprogesterone acetate in the treatment of endometriosis via openalex
Placebo-controlled comparison of danazol and high-dose medroxypro-gesterone acetate in the treatment of endometriosis after conservative surgery via openalex
Progesterone and transforming growth factor-β coordinately regulate suppression of endometrial matrix metalloproteinases in a model of experimental endometriosis via openalex
Progestins for symptomatic endometriosis: a critical analysis of the evidence via openalex
Reduced progesterone action during endometrial maturation: A potential risk factor for the development of endometriosis via openalex
Role of Progesterone Antagonists and New Selective Progesterone Receptor Modulators in Reproductive Health via openalex
RU486-induced growth inhibition of human endometrial cells via openalex
Selective Progesterone Receptor Modulator Development and Use in the Treatment of Leiomyomata and Endometriosis via openalex
Steroidal regulation of endometriosis tissue: lack of induction of 17β-hydroxysteroid dehydrogenase activity by progesterone, medroxyprogesterone acetate, or danazol via openalex
Subcutaneous depot medroxyprogesterone acetate versus leuprolide acetate in the treatment of endometriosis-associated pain via openalex
Subcutaneous injection of depot medroxyprogesterone acetate compared with leuprolide acetate in the treatment of endometriosis-associated pain via openalex
Treatment of endometriosis with a long-acting gonadotropin-releasing hormone agonist plus medroxyprogesterone acetate. via openalex
Treatment of endometriosis with the novel selective progesterone receptor modulator (SPRM) asoprisnil via openalex
Treatment of symptomatic rectovaginal endometriosis with an estrogen–progestogen combination versus low-dose norethindrone acetate via openalex
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W6714620062 via openalex
W2093512443 via openalex
W6717624033 via openalex
W2090747009 via openalex
W2122902311 via openalex
W2223229280 via openalex
W2228635764 via openalex
W2338124628 via openalex
W2032071238 via openalex
W2399716893 via openalex
W2405585157 via openalex

Cited by (30)

Source provenance

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License: CC0 · commercial use OK

[1] All progestins are not created equal via openalex

[2] Antiprogestin and/or gonadotropin-releasing hormone agonist for endometriosis treatment and bone maintenance: a 1-year primate study via openalex

[3] Antiprogestin and/or gonadotropin-releasing hormone agonist for endometriosis treatment and bone maintenance: a 1-year primate study. via openalex

[4] A randomized double-blind prospective trial of two doses of gestrinone in the treatment of endometriosis via openalex

[5] Clinical, endocrine, and metabolic effects of two doses of gestrinone in treatment of pelvic endometriosis via openalex

[6] Cyproterone acetate versus a continuous monophasic oral contraceptive in the treatment of recurrent pelvic pain after conservative surgery for symptomatic endometriosis via openalex

[7] Depot medroxyprogesterone acetate versus an oral contraceptive combined with very-low-dose danazol for long-term treatment of pelvic pain associated with endometriosis via openalex

[8] Dienogest is as effective as triptorelin in the treatment of endometriosis after laparoscopic surgery: results of a prospective, multicenter, randomized study via openalex

[9] Direct effects of medroxyprogesterone acetate, danazol, and leuprolide acetate on endometrial stromal cell proliferation in vitro via openalex

[10] Effect of norethindrone acetate in the treatment of symptomatic endometriosis. via openalex

[11] Endometriosis [ <i>Abridged</i> ] via openalex

[12] Endometriosis therapy with medroxyprogesterone acetate. via openalex

[13] Endometriosis treated with lynestrenol. via openalex

[14] [Endometriosis treated with Lynestrenol]. via openalex

[15] Evaluation of oral medroxyprogesterone acetate in the treatment of endometriosis. via openalex

[16] Gestrinone versus a gonadotropin-releasing hormone agonist for the treatment of pelvic pain associated with endometriosis: a multicenter, randomized, double-blind study via openalex

[17] Human Endometrium and Endometriotic Tissue Obtained Simultaneously via openalex

[18] Immunohistochemical analysis of estrogen and progesterone receptors in endometriosis: comparison with normal endometrium during the menstrual cycle and the effect of medical therapy via openalex

[19] Impact of gestrinone on the course of asymptomatic endometriosis. via openalex

[20] Lipoprotein changes during treatment of pelvic endometriosis with medroxyprogesterone acetate via openalex

[21] Lipoprotein changes during treatment of pelvic endometriosis with medroxyprogesterone acetate. via openalex

[22] MANAGEMENT OF ENDOMETRIOSIS WITH ORAL MEDROXYPROGESTERONE ACETATE via openalex

[23] Megestrol acetate for treatment of endometriosis. via openalex

[24] Placebo-controlled comparison of danazol and high-dose medroxyprogesterone acetate in the treatment of endometriosis via openalex

[25] Placebo-controlled comparison of danazol and high-dose medroxypro-gesterone acetate in the treatment of endometriosis after conservative surgery via openalex

[26] Progesterone and transforming growth factor-β coordinately regulate suppression of endometrial matrix metalloproteinases in a model of experimental endometriosis via openalex

[27] Progestins for symptomatic endometriosis: a critical analysis of the evidence via openalex

[28] Reduced progesterone action during endometrial maturation: A potential risk factor for the development of endometriosis via openalex

[29] Role of Progesterone Antagonists and New Selective Progesterone Receptor Modulators in Reproductive Health via openalex

[30] RU486-induced growth inhibition of human endometrial cells via openalex

[31] Selective Progesterone Receptor Modulator Development and Use in the Treatment of Leiomyomata and Endometriosis via openalex

[32] Steroidal regulation of endometriosis tissue: lack of induction of 17β-hydroxysteroid dehydrogenase activity by progesterone, medroxyprogesterone acetate, or danazol via openalex

[33] Subcutaneous depot medroxyprogesterone acetate versus leuprolide acetate in the treatment of endometriosis-associated pain via openalex

[34] Subcutaneous injection of depot medroxyprogesterone acetate compared with leuprolide acetate in the treatment of endometriosis-associated pain via openalex

[35] Treatment of endometriosis with a long-acting gonadotropin-releasing hormone agonist plus medroxyprogesterone acetate. via openalex

[36] Treatment of endometriosis with the novel selective progesterone receptor modulator (SPRM) asoprisnil via openalex

[37] Treatment of symptomatic rectovaginal endometriosis with an estrogen–progestogen combination versus low-dose norethindrone acetate via openalex

[38] W2007951223 via openalex

[39] W1978310578 via openalex

[40] W1967781227 via openalex

[41] W1910306760 via openalex

[42] W66902808 via openalex

[43] W6600720097 via openalex

[44] W6607068977 via openalex

[45] W6607311167 via openalex

[46] W6643067859 via openalex

[47] W6714620062 via openalex

[48] W2093512443 via openalex

[49] W6717624033 via openalex

[50] W2090747009 via openalex

[51] W2122902311 via openalex

[52] W2223229280 via openalex

[53] W2228635764 via openalex

[54] W2338124628 via openalex

[55] W2032071238 via openalex

[56] W2399716893 via openalex

[57] W2405585157 via openalex