The expression of interstitial collagenase in human endometrium is controlled by progesterone and by oestradiol and is related to menstruation
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Interstitial collagenase is expressed in human endometrium just before and during menstruation, and its expression is regulated by progesterone and estradiol.
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Abstract
Human endometrial tissue, sampled at different periods of the reproductive cycle, expressed interstitial collagenase mRNA, protein and activity only just before and during the menstrual period. This clear-cut correlation and the inhibition of collagenase expression by progesterone and oestradiol in tissue culture point to a pivotal role of this proteinase in the mechanism of menstrual tissue breakdown and bleeding.
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Cited by (36)
- The interaction between inflammation and estrogen in adenomyosis : from molecular mechanisms to therapeutic strategies 2026
- Endometriosis Research: From Bench to Bedside 2022
- PPARγ Agonists: Emergent Therapy in Endometriosis 2021
- Curcumin and Endometriosis 2020
- The Pathogenesis of Endometriosis: Molecular and Cell Biology Insights 2019
- Are matrix metalloproteinases and their inhibitors reliable diagnosis biomarkers and attractive therapeutic targets in endometriosis? 2016
- Mechanisms of endometrial progesterone resistance 2011
- Theories on the Pathogenesis of Endometriosis 2011
- Progestins inhibit expression of MMPs and of angiogenic factors in human ectopic endometrial lesions in a mouse model 2009
- Trimegestone differentially modulates the expression of matrix metalloproteinases in the endometrial stromal cell 2006
- Endocrine regulation of menstruation 2005
- Endocrine regulation of menstruation 2005
- Matrix metalloproteinases in endometrial breakdown and repair: functional significance in a mouse model 2005
- Hormonal regulation and localization of estrogen, progestin and androgen receptors in the endometrium of nonhuman primates: effects of progesterone receptor antagonists 2004
- Pathogenesis of endometriosis 2004
- Focal expression and final activity of matrix metalloproteinases may explain irregular dysfunctional endometrial bleeding 2004
- Differential induction of matrix metalloproteinase 1 and 2 in ectopic endometrium 2003
- Pathogenesis of Endometriosis 2003
- Tissue integrity is essential for ectopic implantation of human endometrium in the chicken chorioallantoic membrane 2003
- Human uterine vascular structures in normal and diseased states 2003
- Circulating ovarian steroids and endometrial matrix metalloproteinases (MMPs) 2002
- Surface vascularization and endometrial appearance in women with menorrhagia or using levonorgestrel contraceptive implants. Implications for the mechanisms of breakthrough bleeding 2002
- Decreased tissue inhibitor of metalloproteinase in the endometrium of women using depot medroxyprogesterone acetate: a role for altered endometrial matrix metalloproteinase/tissue inhibitor of metalloproteinase balance in the pathogenesis of abnormal uterine bleeding? 2002
- Angiogenesis extent and expression of matrix metalloproteinase-2 and -9 agree with progression of ovarian endometriomas 2002
- The Clinical Relevance of Disturbances of Uterine Vascular Growth, Remodeling, and Repair 2001
- Differential regulation of matrix metalloproteinase-3 gene expression in endometriotic lesions compared with endometrium 2001
- A functional model for progestogen-induced breakthrough bleeding 2000
- Transplantation of cultured explants of human endometrium into nude mice 2000
- Endometriosis, Endometrioma, and the Problem of Adhesions 2000
- Local cytokines induce differential expression of matrix metalloproteinases but not their tissue inhibitors in human endometrial fibroblasts 1999
- Metalloproteinases and tissue inhibitor of metalloproteinase 1 (TIMP-1) in endometrial flushings from pre- and post-menopausal women and from women with endometrial adenocarcinoma 1999
- Uterine vascular function and menstruction 1998
- Suppression of matrix metalloproteinases inhibits establishment of ectopic lesions by human endometrium in nude mice 1997
- Peritoneal endometriosis, ovarian endometriosis, and adenomyotic nodules of the rectovaginal septum are three different entities 1997
- Expression of interstitial collagenase (matrix metalloproteinase-1) is related to the activity of human endometriotic lesions 1997
- Focal cellular origin and regulation of interstitial collagenase (matrix metalloproteinase-1) are related to menstrual breakdown in the human endometrium 1996
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