Possible risk of endometriosis for Seveso, Italy, residents: an assessment of exposure to dioxin.
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Seveso, Italy, residents exposed to dioxin after a 1976 accident experienced cumulative exposure levels exceeding those in monkeys that developed endometriosis, suggesting they form an ideal cohort to study endometriosis risk.
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Abstract
A recent study by Rier et al. showed that rhesus monkeys exposed daily for 4 years to 5 or 25 ppt of dioxin in food develop endometriosis, with incidence and severity related to dose. We aimed to determine whether the total time-integrated dioxin exposure of a human population could be comparable to that of Rier's monkeys. We selected a sample of residents of Seveso, Italy, who were acutely exposed to high levels of dioxin following an accident in 1976. We conducted a toxicokinetic analysis which takes into account species and exposure differences in dose and timing between humans and monkeys. The area under the time-concentration curve for dioxin in fat, which corresponds to cumulative exposure over time, ranges for some of the most heavily exposed Seveso residents from approximately 1.7 x 10(6) ppt-days to 1.1 x 10(8) ppt-days. These values exceed in all cases the values for the monkeys exposed to 25 ppt or 5 ppt. Given their exposure, the Seveso population should be an ideal epidemiologic cohort to rule out or confirm whether exposure to dioxin leads to an increased risk of endometriosis in humans.
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References (7)
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Cited by (19)
- Endocrine Disruption in Women: A Cause of PCOS, Early Puberty, or Endometriosis 2023
- influence of dioxines on endometriosis development – study review 2022
- Exposure to the environmental endocrine disruptor TCDD and human reproductive dysfunction: Translating lessons from murine models 2016
- Environmental Influences on the Development of Endometriosis 2013
- Endométriose profonde et fertilité 2011
- Endometriosis in the African American woman—racially, a different entity? 2011
- Endométriose rectale et fertilité 2008
- Organochlorines and endometriosis: A mini-review 2007
- Outcome of laparoscopic colorectal resection for endometriosis 2007
- Associations between serum levels of selected organochlorine compounds and endometriosis in infertile Japanese women 2005
- Serum dioxin concentrations and endometriosis: a cohort study in Seveso, Italy. 2002
- Tampons, dioxins, and endometriosis 2001
- Human health effects of dioxins: cancer, reproductive and endocrine system effects 2001
- Redefining endometriosis: Endometriosis is an entity with extreme pleiomorphism 2000
- Estrogen Receptor Reduces CYP1A1 Induction in Cultured Human Endometrial Cells 1999
- The Physiopathology of Endometriosis: Pollution and Dioxin 1999
- Genetic influences on endometriosis in an Australian twin sample 1999
- Endometriosis: a dysfunction and disease of the archimetra 1998
- THE STRUCTURE AND FUTURE OF ENDOMETRIOSIS RESEARCH 1997
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- pubmed
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