Impact of Continuous Estroprogestin Treatment on Circulating Microparticle Levels in Deep Endometriosis Patients

P. Carrillo Torres, Pilar Carrillo Torres, Maria Ángeles Martínez‐Zamora, María Ángeles Martínez-Zamora, Dolors Tàssies, Helena Castillo‐Ecija, Helena Castillo, Meritxell Gracia, Meritxell Gràcia, Georgina Feixas, Joan Carles Reverter, Francisco Carmona
International journal of molecular sciences · 2023 · vol. 24(14) , pp. 11802 · doi:10.3390/ijms241411802 · PMID:37511561 · W4385161805
article OA: gold CC0 ⤵ 4 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Continuous estroprogestin treatment reduced circulating microparticle levels in deep endometriosis patients, while increasing microparticles expressing tissue factor compared to untreated patients.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

There has been increasing interest in the study of new pathogenic mechanisms in endometriosis (END), including the coagulation/fibrinolysis system and its link with inflammation and tissue remodeling. It has been suggested that END patients, especially with deep-infiltrating (DE) forms, could present a hypercoagulable state revealing higher levels of proinflammatory and procoagulant markers, such as total circulating microparticles (cMPs) and cMP-TF (tissue factor), released by cells in response to damage, activation, or apoptosis. However, no previous study has assessed the effect of END hormonal treatments on cMP and cMP-TF levels. Therefore, the aim of this study was to evaluate the impact of these treatments on cMP and cMP-TF levels in DE patients. Three groups were compared: DE patients receiving a continuous combined oral contraceptive regimen (CCOCR) (n = 41), DE patients without CCOCR (n = 45), and a control group (n = 43). cMP and cMP-TF levels were evaluated in platelet-free plasma. A significant decrease in the total cMP levels was found in the DE group with CCOCR versus the group without CCOCR, reflecting a higher chronic inflammatory status in DE patients that decreased with the treatment. cMP-TF levels were higher in DE patients receiving CCOCR versus those not receiving CCOCR, suggesting that treatments containing estrogens play a predominant role in suppressing the inhibitory pathway of TF.

My notes (saved in your browser only)

Condition tags

mesh:D004715endometriosis

MeSH descriptors

Cell-Derived Microparticles Cell-Derived Microparticles Cell-Derived Microparticles Cell-Derived Microparticles Cell-Derived Microparticles Cell-Derived Microparticles Cell-Derived Microparticles Cell-Derived Microparticles Cell-Derived Microparticles Cell-Derived Microparticles Cell-Derived Microparticles Cell-Derived Microparticles Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (40)

Cited by (4)

Source provenance

europepmc
last seen: 2026-06-04T01:30:01.192114+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-06-04T00:33:39.328528+00:00
License: CC0 · commercial use OK