Safety of ultrasound-guided high-intensity focused ultrasound ablation for diffuse adenomyosis: A retrospective cohort study

Feng Y, Yujie Feng, Hu L, Liang Hu, Chen W, Wenzhi Chen, Zhang R, Rong Zhang, Wang X, Xi Wang, Jinyun Chen, Chen J
Ultrasonics sonochemistry · 2016 · vol. 36 , pp. 139–145 · doi:10.1016/j.ultsonch.2016.11.022 · PMID:28069193 · W2555385411
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This retrospective cohort study assessed the safety of ultrasound-guided high-intensity focused ultrasound (HIFU) ablation for diffuse adenomyosis, finding it to be a safe treatment option.

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Abstract

OBJECTIVES: To evaluate the safety of ultrasound-guided high-intensity focused ultrasound (HIFU) ablation for patients with diffuse adenomyosis. METHODS: This was a retrospective cohort study. The data was collected from 417 symptomatic adenomyosis patients who underwent ultrasound-guided HIFU between January 2012 and December 2015 at 1st Affiliated Hospital of Chongqing Medical University, Chongqing, China. Among them were 260 patients with diffuse adenomyosis (Group D) and 157 patients with focal adenomyosis (Group F). All patients underwent contrast-enhanced magnetic resonance imaging (MRI) one week before and the day after HIFU treatment. Successful treatment with HIFU was measured by the non-perfused volume ratio (NPVR). Intraprocedural and postprocedural adverse effects and complications were recorded to assess the safety of the procedure. Patients were followed-up for three months post-treatment. Complications were given a grade A through F according to the SIR Standards. RESULTS: All patients successfully completed the procedure, non-perfused regions appeared in 415 (99.5%) patients. The non-perfused volume ratio (NPVR) of Group D was significantly lower than that of Group F (P<0.05). During the procedure, the odds ratio of skin-burning pain was 1.7 (OR=1.617, 95% CI: 1.103-2.532), when comparing Group D with Group F, while the odds ratio of inguinal pain was equal to 2.0 (OR=2.038, 95% CI: 1.161-3.580), when Group F was compared to Group D. 97 patients (23.3%) received nominal therapy due to complications ([Society of interventional radiology, SIR]-B grade), among them, there were 62 cases (23.8%) in Group D and 35 cases (22.3%) in Group F. No significant difference was found between the two groups (P>0.05) and neither of the reported complications of SIR-C-SIR-F occurred within the two groups. CONCLUSIONS: Based on our results, ultrasound-guided HIFU is safe for the treatment of diffuse adenomyosis, and controlling the ablation zone is crucial to ensure patients' safety.

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Condition tags

adenomyosis

MeSH descriptors

Adenomyosis High-Intensity Focused Ultrasound Ablation Safety Safety Adenomyosis Adenomyosis Adolescent Adolescent Adult Adult Female Female High-Intensity Focused Ultrasound Ablation High-Intensity Focused Ultrasound Ablation Humans Humans Middle Aged Middle Aged Retrospective Studies Retrospective Studies

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