Fertility after discontinuation of treatment with an oral contraceptive containing 30 microg of ethinyl estradiol and 2 mg of dienogest

Inka Wiegratz, Katrin Mittmann, Horst Dietrich, H. Dietrich, Thomas Zimmermann, Herbert Kühl, Herbert Kuhl
Fertility and sterility · 2006 · vol. 85(6) , pp. 1812–1819 · doi:10.1016/j.fertnstert.2005.11.052 · PMID:16759929 · W2036128893
Non-randomised trial OA: bronze CC0 ⤵ 2 in-corpus citations
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This paper examined the return of fertility in women after stopping an oral contraceptive containing 30 μg ethinyl estradiol and 2 mg dienogest.

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Abstract

OBJECTIVE: To examine the conception rate after cessation of a combination of 30 microg ethinyl E2 and 2 mg dienogest (EE/DNG). DESIGN: Prospective observational study. SETTING: Population-based cohort in Germany. PATIENT(S): Women who wished to become pregnant after cessation of an oral contraceptive (EE/DNG). INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Cumulative conception rate within 1 year after termination of EE/DNG and time to pregnancy. RESULT(S): After 1 year of follow-up, the cumulative pregnancy rate was 86.6% (full analysis set; n = 706). When all participants with complete data were analyzed (n = 652), the cumulative pregnancy rate was 94.0%. More than 15% of the patients conceived in each of the first three cycles after termination of EE/DNG; the mean time to pregnancy was 3.5 cycles. The preceding duration of treatment with EE/DNG did not influence the conception rate. Except in the youngest age group (16-18 years), a certain delay was observed in the other age groups. CONCLUSION(S): The present prospective study revealed only a slight delay in regaining fertility during the first three cycles after cessation of EE/DNG. Thereafter, the cumulative rate of conception did not differ from that observed in fertile women who attempted to become pregnant without prior contraception.

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MeSH descriptors

Ethinyl Estradiol Fertility Nandrolone Pregnancy Rate Withholding Treatment Adult Age Distribution Contraceptives, Oral, Combined Contraceptives, Oral, Hormonal Estrogens Estrogens Ethinyl Estradiol Female Fertility Germany Germany Humans Nandrolone Nandrolone Outcome Assessment, Health Care

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