Inka Wiegratz

BACKGROUND: Heavy menstrual bleeding (HMB) is a common complication of anticoagulant therapy in menstruating women with venous thromboembolism (VTE). Direct oral anticoagulants (DOAC) used for VTE treatment may differ in their menstrual ble…

BACKGROUND: The use of recombinant human follicle-stimulating hormone (r-hFSH) in ovarian stimulation protocols for infertility treatment in assisted reproductive technology (ART) clinical practice is well established. More recent advanceme…

BACKGROUND: The present study compared the efficacy and safety of a combined oral contraceptive containing 30 mcg ethinylestradiol and 2 mg dienogest (EE/DNG) in conventional and extended-cycle regimen over 1 year of treatment. STUDY DESIG…

BACKGROUND: In Germany today, one-third of the 20 million women of child-bearing age use combined oral contraceptives (COCs). In this article, we summarize the current knowledge of the mode of action, wanted and unwanted side effects, and l…

OBJECTIVES: To investigate prescribing preferences and personal experience of female gynaecologists with extended-cycle use of combined oral contraceptives (COCs) in Germany and Austria. METHODS: A questionnaire on prescribing patterns and…

BACKGROUND: The effects of extended regimens of combined oral contraceptives (COC) on lipid parameters are largely unknown. The present study compared the effects of a COC containing 30 mcg ethinyl estradiol and 2 mg dienogest (EE/DNG) in c…

BACKGROUND: This study was conducted to investigate the effects of an oral contraceptive containing 30 mcg ethinyl estradiol and 2 mg dienogest on thyroid hormones and androgen parameters. STUDY DESIGN: Thyroid and androgen parameters were…

BACKGROUND: The study was conducted to investigate the effect of a combined oral contraceptive (COC) containing 30 mcg ethinylestradiol and 2 mg dienogest with two different regimens on various hemostasis variables. STUDY DESIGN: Hemostati…

OBJECTIVE: Enlargement of the junctional zone (JZ) on T2-weighted resonance imaging of the uterus has recently been established as the major criterion for adenomyosis in patients with endometriosis. This study was conducted to analyse the e…

Einleitung: Gewebeproben von peritonealer Endometriose, Adenomyose und von basalem Endometrium zeigten die gleichen zyklischen immunhistochemischen Veränderungen bezüglich der Hormonrezeptoren sowie der P-450 Aromatase*. Da beschrieben wurd…

OBJECTIVE: To illustrate the influence of pregnancy on primary umbilical endometriosis. DESIGN: Case report. SETTING: Gynecologic endocrinology outpatient department of a university hospital. PATIENT(S): 27-year-old nulliparous woman. I…

The uterus is composed of different smooth muscle layers that serve various functions. First, menstrual debris is expulsed at the time of the menses. Second, sperm is transported in the preovulatory phase to maximize fertility, and third, t…

Fragestellung: In letzter Zeit mehren sich die Hinweise, dass eine Adenomyose mit einer Prävalenz von bis zu 85% bei Endometriose vorliegt. Der Ausprägungsgrad der Adenomyose ist von entscheidender Bedeutung für die Fertilität der Patientin…

Hintergrund: Die Erweiterung der Übergangszone ("junctional Zone", JZ) in der Magnetresonanztomographie (MRI) gilt als Hauptkriterium der Adenomyose1. Da die schwere Dysmenorrhoe das Leitsymptom der Endometriose darstellt, aber nie mit eine…

During the use of long-cycle regimens of monophasic oral contraceptives, the total number of bleeding and cycle-dependent complaints is considerably lower than during conventional treatment with oral contraceptives. Despite an initially hig…

OBJECTIVE: To examine the conception rate after cessation of a combination of 30 microg ethinyl E2 and 2 mg dienogest (EE/DNG). DESIGN: Prospective observational study. SETTING: Population-based cohort in Germany. PATIENT(S): Women who w…

OBJECTIVE: Uterine hyperperistalsis and dysperistalsis are common phenomena in endometriosis and may be responsible for reduced fertility in cases of minimal or mild extent of disease. Since a high prevalence of adenomyosis uteri has been w…

endometriums with endometriosis, which were labeled with Cy5-dUTP. Fluorescent labeled probes were hybridized on a microarray of 4800 human genes. Results: We could detect many genes expressed differently in eutopic endometrium with or with…

Hintergrund: Gewebe von Endometriose-und Adenomyoseherden imitieren die zyklischen Veränderungen der Hormonrezeptoren des basalen Endometriums. Da der Nachweis erbracht wurde, dass bei Patientinnen mit Endometriose eine höhere Prävalenz an …

This is the first double-blind, controlled, randomized study comparing the effect of different estrogen components in oral contraceptives (OCs) on hemostasis variables. Four groups of 25 women each were treated for six cycles with monophasi…

The conventional regimen of oral contraceptive (OC) use mimics the natural cycles by causing regular withdrawal bleeding, which can be avoided by omission of the hormone-free interval of 7 days. Consequently, long-cycle regimens with contin…

In a double-blind, controlled, randomized, four-arm, bicentric clinical study, the effect of four oral contraceptives (OCs) on thyroid hormone parameters, cortisol, aldosterone, endothelin-1 and angiotensin II was investigated. Four groups …

In a double-blind, controlled, randomized, four-arm, bicentric clinical study, the effect of four oral contraceptives (OCs) on lipid metabolism was investigated. Four groups composed of 25 volunteers each (mean age 26.1 +/- 4.5 years; body …