Imbalance in cytokines from interleukin-1 family - role in pathogenesis of endometriosis

Justyna Sikora, Aleksandra Mielczarek-Palacz, Aleksandra Mielczarek‐Palacz, Zdzislawa Kondera-Anasz, Zdzisława Kondera‐Anasz
American journal of reproductive immunology (New York, N.Y. : 1989) · 2012 · vol. 68(2) , pp. 138–145 · doi:10.1111/j.1600-0897.2012.01147.x · PMID:22537218 · W2107945104
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This study found elevated IL-1beta and ICE levels but lower IL-18 levels in peritoneal fluid from women with endometriosis, indicating impaired IL-1 cytokine family secretion.

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Abstract

PROBLEM: To assess whether interleukin (IL)-1beta, IL-18 and interleukin-1 converting enzyme (ICE) are involved in the pathogenesis of endometriosis. METHOD OF STUDY: Peritoneal fluid (PF) was obtained from 85 women with and without endometriosis. Peritoneal macrophages were cultured and the culture media collected. IL-1beta, IL-18 and ICE levels were measured by the enzyme-linked immunosorbent assay (ELISA). RESULTS: Levels of IL-1beta and ICE in PF of women with endometriosis were higher than those in the control group. However, PF level of IL-18 was significantly lower in the study group than in the controls. Higher secretion of IL-1beta by peritoneal macrophages and lower IL-18 and ICE in endometriosis patients than in control were observed. Following lipopolysaccharide (LPS) stimulation, the macrophages secreted more IL-1beta, IL-18 and ICE in all groups. CONCLUSIONS: The results pointed to impairment of the secretion of the IL-1 cytokine family in endometriosis. Invalid IL-1beta and IL-18 maturation by ICE may be an important pathogenic factor in endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Caspase 1 Endometriosis Interleukin-18 Interleukin-1beta Macrophages, Peritoneal Adult Adult Caspase 1 Caspase 1 Caspase 1 Cells, Cultured Cells, Cultured Endometriosis Endometriosis Enzyme-Linked Immunosorbent Assay Enzyme-Linked Immunosorbent Assay Female Female Gene Expression Regulation Gene Expression Regulation

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References (31)

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