Intestinal microbiota-associated LysoPC(16:0) promotes endometriosis via PPARγ-mediated M2 macrophage polarization and IL-10 secretion

Na Li, Ming Yuan, Xueyang Jin, Xue Jiao, Shuang Wang, Zhaoyang Zhong, Hongwei Guan, Le Xu, Qianhui Ren, Yu Liu, Xiaoyu Dong, Qiuju Li, Mei Wang, Guoyun Wang
In: iScience · 2026 · vol. 29(11) , pp. 117917 · doi:10.1016/j.isci.2026.117917 · W7221926320
Lab / animal OA: gold CC0
🔓 Open OA copy View on OpenAlex View at publisher
⚙ AI-generated summary by qwen3.7-flash, 2026-10-19 ⓘ

Intestinal microbiota-derived LysoPC(16:0) promotes endometriosis by activating PPARγ to drive M2 macrophage polarization and IL-10 secretion, thereby enhancing lesion growth and stromal cell migration.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Both gut microbiota dysbiosis and altered pelvic immune microenvironment have been linked to endometriosis (EM), but the metabolites connecting the two remain undefined. Combining 16S rDNA sequencing with non-targeted metabolomics in a murine EM model, we found altered gut microbiota composition alongside a marked rise in peritoneal lysophosphatidylcholine (LysoPC(16:0)), linked to the microbiota shift by correlation analysis and fecal transplantation. LysoPC(16:0) promoted M2 macrophage polarization through peroxisome proliferator-activated receptor gamma (PPARγ), an effect observed in two mouse strains. Clodronate-mediated macrophage depletion blocked LysoPC(16:0)-driven lesion growth. LysoPC(16:0) further induced PPARγ-dependent IL-10 transcription, and IL-10 neutralization in vivo reduced lesion weight. Conditioned medium from LysoPC(16:0)-stimulated THP-1 macrophages promoted migration of primary endometrial stromal cells from patients with EM, an effect reversed by GW9662 or IL-10 neutralization. Together, these results outline a gut microbiota-LysoPC(16:0)-PPARγ-M2–IL-10 axis in EM pathogenesis, a mechanistic and therapeutic target for future clinical study.

My notes (saved in your browser only)

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (49)

Source provenance

openalex
last seen: 2026-10-22T06:00:29.164115+00:00
License: CC0 · commercial use OK