Diagnosis and management of endometriosis

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This paper defines endometriosis as a chronic condition of endometrial-like tissue outside the uterus causing estrogen-driven inflammation and outlines its diagnosis and management.

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This 2023 CMAJ review summarizes the epidemiology, pathophysiology, diagnosis, and management of endometriosis, drawing on human adult research, clinical guidelines, systematic reviews, and randomized trials identified via a targeted (nonsystematic) MEDLINE search. It reports that endometriosis affects about 10% of women of reproductive age, can involve superficial to deep and extrapelvic disease, has no cure, and that while surgery can provide definitive histopathology, many international guidelines now recommend a nonsurgical clinical diagnosis using symptoms, physical exam, and imaging to reduce treatment delays. The review also highlights that disease natural history is variable—progression occurs in 29%–45% of untreated patients, unchanged in 33%–42%, and regression in 22%–29%—and that persistent pain despite complete treatment may involve central sensitization or nociplastic pain. A major caveat is that the review is explicitly based on targeted nonsystematic literature searches rather than a systematic review. This paper is centrally about endometriosis — it reviews diagnosis and management across the spectrum of disease and pain mechanisms.

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Abstract

[For a first-person account of endometriosis, see www.cmaj.ca/lookup/doi/10.1503/cmaj.230215][1] KEY POINTS Endometriosis is a chronic condition defined by the presence of endometrial-like tissue outside of the uterus, which can lead to estrogen-driven inflammation. The extent of disease can be
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Conclusion

Endometriosis is a common and complex condition that can cause considerable distress and can lead to the development of chronic pelvic pain, infertility or end-organ damage. Early recog- nition and diagnosis are key to providing timely treatment. Pri- mary care providers can make a clinical diagnosis of endometri- osis and start first-line medical management. Referral to a gynecologist for second-line hormonal therapy or surgery is important, when indicated. Hormonal or surgical treatments can provide symptom relief and are part of a long-term management plan for this chronic condition. Multidisciplinary care may be required to address complex persistent pain.

References

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Jarrell JF, Vilos GA, Allaire C, et al.; Chronic Pelvic Pain Working Group. SOGC. Consensus guidelines for the management of chronic pelvic pain. J Obstet Gyn- aecol Can 2005;27:781-826. 55. Mills S, Torrance N, Smith BH. Identification and management of chronic pain in primary care: a review. Curr Psychiatry Rep 2016;18:22. Competing interests: Catherine Allaire reports conference support from Hologic and participation on advisory boards with AbbVie and Pfizer. She is a board member with the Canadian Society for the Ad- vancement of Gynecologic Excellence, the International Pelvic Pain Society and the World Endometriosis Society. Mohamed Bedaiwy re- ports funding from the Canadian Institutes of Health Research (CIHR) and the Ferring Women Health Research Institute, royalties from AbbVie and Baxter, consulting fees from AbbVie and participation with the board of the Canadian Fertility and Andrology Society. Paul Yong reports funding from CIHR, Michael Smith Health Research BC, the Women’s Health Research Institute, the University of British Columbia and the International Society for the Study of Women’s Sexual Health. He reports meeting support from the Canadian Soci- ety for the Advancement of Gynecologic Excellence, the International Society for the Study of Women’s Sexual Health, the International Pelvic Pain Society and the World Endometriosis Society. He also sits on the data safety monitoring board a for CIHR-funded clinical trial, the strategic advisory board for the Women’s Health Research Institute,the boards of the Canadian Society for the Advancement of Gynecologic Excellence, the International Society for the Study of Women’s Sexual Health and the World Endometriosis Society. No other competing interests were declared. This article was solicited and has been peer reviewed. Affiliations: Department of Obstetrics and Gynecology, University of British Columbia; BC Women’s Centre for Pelvic Pain and Endometri- osis, Vancouver, BC Contributors: All of the authors contributed to the conception and design of the work, drafted the manuscript, revised it critically for important intellectual content, gave final approval of the version to be published and agreed to be accountable for all aspects of the work. Content licence: This is an Open Access article distributed in accord- ance with the terms of the Creative Commons Attribution (CC BY-NC-ND 4.0) licence, which permits use, distribution and reproduction in any medium, provided that the original publication is properly cited, the use is noncommercial (i.e., research or educational use), and no modifi- cations or adaptations are made. See: https://creativecommons.org/ licenses/by-nc-nd/4.0/ Correspondence to: Catherine Allaire, [email protected]

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Condition tags

mesh:D004715mesh:D017699endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Female Female Female Female Humans Humans Humans Humans Pelvic Pain Pelvic Pain Pelvic Pain Pelvic Pain

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