Diagnosis and management of endometriosis
This paper defines endometriosis as a chronic condition of endometrial-like tissue outside the uterus causing estrogen-driven inflammation and outlines its diagnosis and management.
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This 2023 CMAJ review summarizes the epidemiology, pathophysiology, diagnosis, and management of endometriosis, drawing on human adult research, clinical guidelines, systematic reviews, and randomized trials identified via a targeted (nonsystematic) MEDLINE search. It reports that endometriosis affects about 10% of women of reproductive age, can involve superficial to deep and extrapelvic disease, has no cure, and that while surgery can provide definitive histopathology, many international guidelines now recommend a nonsurgical clinical diagnosis using symptoms, physical exam, and imaging to reduce treatment delays. The review also highlights that disease natural history is variable—progression occurs in 29%–45% of untreated patients, unchanged in 33%–42%, and regression in 22%–29%—and that persistent pain despite complete treatment may involve central sensitization or nociplastic pain. A major caveat is that the review is explicitly based on targeted nonsystematic literature searches rather than a systematic review. This paper is centrally about endometriosis — it reviews diagnosis and management across the spectrum of disease and pain mechanisms.
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Cited by (50)
- Effect of mindful breathing on anxiety, depression, and quality of life among women with endometriosis 2026
- Vexing Fringes of Endometriosis: A Case Series 2026
- The Role of Nursing in Gynecological Care: Strategies for Comprehensive Women’s Care 2026
- Variation in endometriosis aetiology, potential impact on lesion heterogeneity and the consequences for research and treatment 2026
- Endometriosis-Associated Infertility: A Review of Pathophysiological Mechanisms and Current Treatment Strategies 2026
- Resveratrol as a protective and ameliorative agent in endometriosis 2026
- Dry Eye-Related Ocular Surface Assessment in a Pooled Endometriosis/Adenomyosis Cohort: A Real-World Case–Control Study 2026
- Gastrointestinal tract endometriosis: Clinicopathologic features and anatomic distribution in an institutional cohort 2026
- Hypoxia-mediated epigenetic silencing of YTHDF2 promotes endometriosis progression via the NFE2L1-NF-κB axis 2026
- Paeonia × suffruticosa Andrews leaves improve endometriosis with anxiety/depression by regulating microglial polarization via JAK2/STAT3 pathway 2026
- Medical and Surgical Management of Endometriosis: A Narrative Review of Clinical Outcomes 2026
- The Impact of Endometriosis on Ovarian Reserve: A Systematic Review 2026
- The Endometriosis-Related Healthcare Experiences of Regional Australian Women: A Qualitative Systematic Review 2026
- Incremental Diagnostic Value of the Plasma Kynurenine/Tryptophan Ratio for Deep Infiltrating Endometriosis and Its Correlation With Eutopic Endometrial Matrix Metalloproteinase-9 Expression: A Single-Center Prospective Study 2026
- Associations between biological aging and the risk of endometriosis: Evidence from a large population-based prospective cohort study 2025
- The role of purinergic P2X3 receptors and endometriosis-associated hyperalgesia 2025
- HOXC4 promotes proliferation of endometriotic stromal cells via the SLIT2–ROBO1 axis 2025
- Peculiarities of ethanol sclerotherapy of ovarian endometriomas in women of active reproductive age (literature review) 2025
- Luminescent mouse model of endometriosis: three-dimensional morphology of lesions and cytokine profiles 2025
- Targeting EphA2 suppresses the proliferation, migration and invasion of endometriosis <i>via</i> the AMPK signaling pathway 2025
- Elagolix - a novel drug for management of endometriosis and uterine fibroids 2025
- Acceptance and Commitment Therapy Intervention for Individuals with Endometriosis and Persistent Pelvic Pain 2025
- Current Insights into Endometriosis: Hormonal Management, Clinical Outcomes, and Opportunities for Progress 2025
- Diagnóstico y manejo actual de la endometriosis: revisión narrativa 2025
- Debunking the “Mystical Condition” of Endometriosis: What People Living with Endometriosis Want You to Truly Understand 2025
- ABSTRACT DETERMINATION OF THE OVARIAN TISSUE DESTRUCTION DEGREE AS A RESULT OF SURGICAL TREATMENT OF ENDOMETRIOMAS IN WOMEN OF REPRODUCTIVE AGE 2025
- Barriers to gender affirming healthcare for transgender and non-binary people with endometriosis 2025
- Endometriosis: a new look at an old problem 2025
- Trends in Endometriosis Management: A 10-Year US Claims Analysis 2025
- Logistic regression analysis of pregnancy outcome and EFI score of infertile patients with ovarian endometriosis cyst after staged oral administration of traditional Chinese medicine 2025
- Comparison of Machine Learning Models for Long-Term Recurrence of Endometriosis Treated by Laparoscopy Combined With GnRHa 2025
- Endometriosis: current challenges and treatment prospects 2025
- Comparison of quality of life in patients with endometriosis undergoing treatment with progestins, oral contraceptives pills (OCP), and GnRH agonists 2025
- Screening for endometriosis: A scoping review of screening measures that could support early diagnosis 2025
- Impact of Minimally Invasive Surgery on Quality of Life and Infertility in Deep Infiltrating Endometriosis 2025
- Analysis of clinical factors in endometriosis of the abdominal wall 2025
- Health-related decision-making experiences of people with endometriosis: a qualitative analysis 2025
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