Paracrine Regulation of Matrix Metalloproteinase Expression in the Normal Human Endometrium

Kevin G. Osteen, K G Osteen, N R Keller, Nancy R. Keller, F A Feltus, F. Alex Feltus, Michael H. Melner, M H Melner
Gynecologic and obstetric investigation · 1999 · vol. 48(Suppl. 1) , pp. 2–13 · doi:10.1159/000052863 · PMID:10559659 · W2030973262
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Abstract

Endometrial expression of matrix metalloproteinase (MMP)-3, MMP-7 and MMP-11 occurs during menstrual breakdown and subsequent estrogen-mediated growth, but not during the secretory phase. These enzymes are suppressed by progesterone treatment. Paracrine factors, including transforming growth factor-beta (TGF-beta) and retinoic acid, are also critical for MMP regulation in the endometrium. In contrast, inflammatory cytokines such as interleukin-1alpha may block or interfere with steroid-mediated MMP regulation at ectopic sites of growth. Using in vitro models, our laboratory has investigated the complex interactions between progesterone and locally produced cytokines that may affect MMP expression during the development of endometriosis. Our results indicate that targeting the regulation of MMPs may represent an appropriate therapeutic strategy for the treatment of endometriosis. Copyrightz1999S. KargerAG,Basel

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometrium Gene Expression Regulation, Enzymologic Matrix Metalloproteinases Adult Blotting, Western Chromatography, Thin Layer Endometriosis Endometriosis Endometriosis Endometrium Endometrium Estradiol Estradiol Female HeLa Cells Humans Interleukin-1 Interleukin-1 Matrix Metalloproteinase 11

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