Effects of early endometriosis on IVF-ET outcomes

Keiko Mekaru, Chiaki Yagi, Kozue Asato, Hitoshi Masamoto, Kaoru Sakumoto, Yoichi Aoki
Frontiers in bioscience (Elite edition) · 2012 · vol. E5(2) , pp. 720–724 · doi:10.2741/e652 · PMID:23277026 · W2013100981
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Early-stage endometriosis was associated with increased gonadotropin requirements, fewer high-quality embryos, and lower pregnancy and live birth rates during IVF-ET cycles.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 · read from full text ⓘ

This study examined IVF-ET outcomes in women under 40 with unexplained infertility by enrolling 35 participants and comparing 18 with stage I/II endometriosis (39 IVF-ET cycles) to 17 without endometriosis (41 cycles). The endometriosis group required higher total gonadotropin, had a lower percentage of high-quality embryos among fertilized eggs (9.0% vs 16.3%), and showed lower pregnancy and live birth rates (33.3% vs 41.5% and 25.6% vs 34.1%). The authors reported that no statistically significant overall effect on IVF-ET outcome was observed, with the caveat that ovarian response and embryo quality appeared reduced in stage I/II endometriosis. This paper is centrally about endometriosis — specifically early-stage (stage I/II) endometriosis effects on IVF-ET outcomes and embryo quality.

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Abstract

There have been very few reports on the outcomes of in vitro fertilization and embryo transfer (IVF-ET) in women with stage I/II endometriosis. The objective of this study was to investigate IVF-ET outcomes in women with early-stage endometriosis. We enrolled 35 women less than 40 years with unexplained infertility who underwent IVF-ET into the study. We compared 18 women with stage I/II endometriosis according to the revised American Society for Reproductive Medicine classification for endometriosis, who underwent 39 IVF-ET cycles (En (+) group) with 17 women without endometriosis who underwent 41 IVF-ET cycles (En (-) group). Higher requirements of total gonadotropin, a lower percentage of high-quality embryos of all fertilized eggs (9.0% vs. 16.3%), a relatively lower pregnancy rate (33.3% vs. 41.5%), and a lower live birth rate (25.6% vs. 34.1%) were observed in the En (+) group. Although no significant effect on IVF-ET outcome was observed, ovarian response may be decreased in women with stage I/II endometriosis. Considering the decreased number of high-quality embryos in the En (+) group, stage I/II endometriosis may have detrimental effects on embryo quality.
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Abstract

There have been very few reports on the outcomes of in vitro fertilization and embryo transfer (IVF- ET) in women with stage I/II endometriosis. The objective of this study was to investigate IVF-ET outcomes in women with early-stage endometriosis. We enrolled 35 women less than 40 years with unexplained infertility who underwent IVF-ET into the study. We compared 18 women with stage I/II endometriosis according to the revised American Society for Reproductive Medicine classification for endometriosis, who underwent 39 IVF-ET cycles [En (+) group] with 17 women without endometriosis who underwent 41 IVF-ET cycles [En (−) group]. Higher requirements of total gonadotropin, a lower percentage of high-quality embryos of all fertilized eggs (9.0% vs. 16.3%), a relatively lower pregnancy rate (33.3% vs. 41.5%), and a lower live birth rate (25.6% vs. 34.1%) were observed in the En (+) group. Although no significant effect on IVF-ET outcome was observed, ovarian response may be decreased in women with stage I/II endometriosis. Considering the decreased number of high-quality embryos in the En (+) group, stage I/II endometriosis may have detrimental effects on embryo quality.

Keywords

- Early endometriosis - In vitro fertilization and embryo transfer - Laparoscopy

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Embryo Transfer Endometriosis Fertilization in Vitro Infertility, Female Adult Embryo Transfer Endometriosis Endometriosis Female Fertilization in Vitro Humans Infertility, Female Infertility, Female Pregnancy Pregnancy Rate Retrospective Studies Statistics, Nonparametric Treatment Outcome

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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