The progins progesterone receptor gene polymorphism is not related to endometriosis-associated infertility or to idiopathic infertility

Cristiane Gimenes, Bianca Bianco, Fernanda Mafra, Fernanda Abani Mafra, Victor Rosset, Denise Maria Christofolini, Caio Parente Barbosa
Clinics (Sao Paulo, Brazil) · 2010 · vol. 65(11) , pp. 1073–1076 · doi:10.1590/s1807-59322010001100002 · PMID:21243274 · W2160366014
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study found that the PROGINS polymorphism in the progesterone receptor gene was not associated with endometriosis-associated infertility or idiopathic infertility in the studied population.

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The study evaluated whether a progesterone receptor gene polymorphism (progins) is associated with infertility, specifically comparing endometriosis-associated infertility and idiopathic infertility. It used a genetic association approach in affected populations, analyzing the presence of the polymorphism relative to infertility outcomes across groups. The key finding was that the progins progesterone receptor gene polymorphism was not related to either endometriosis-associated infertility or idiopathic infertility. The paper’s main limitation is that the text provided does not include details on sample size, statistical power, or methods. This paper is centrally about endometriosis — it directly tests whether a progesterone receptor gene polymorphism relates to endometriosis-associated infertility.

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Abstract

OBJECTIVE: This study aimed to determine the frequency of the PROGINS polymorphism in women with endometriosis-associated infertility, in infertile women without endometriosis and in controls. INTRODUCTION: The human progesterone receptor gene has two isoforms that modulate the biological action of progesterone: isoform A, which is capable of inhibiting the activation of the estrogen receptors, and isoform B, which has the capacity to activate the estrogen receptors. Several polymorphisms have been described for this gene, among which one stands out: a polymorphism named PROGINS, which has been speculated to be related to the genesis of endometriosis by several studies with conflicting results. METHODS: This was a prospective study that included 148 patients with endometriosis-associated infertility, 50 idiopathic infertile patients and 179 fertile women as controls. The PROGINS polymorphism was studied by PCR. RESULTS: Genotypes P1P1, P1P2 and P2P2 (P2 representing the PROGINS polymorphism) of the progesterone receptor gene presented frequencies of 93.9%, 5.4% and 0.7%, respectively, in the women with endometriosis-associated infertility (p=0.2101, OR=0.51, 95% CI=0.24-1.09); 94.4%, 4.2% and 1.4%, respectively, in the patients with minimal/mild endometriosis (p=0.2725, OR=0.53, 95% CI=0.20-1.43); 93.5%, 6.5% and 0%, respectively, among the patients with moderate/severe endometriosis (p=0.3679, OR=0.49, 95% CI=0.18-1.31); 86.0%, 14.0% and 0%, respectively, in idiopathic infertile women (p=0.8146, OR=1.10, 95% CI=0.46-2.63); and 88.3%, 10.6% and 1.1%, respectively, in the control group. CONCLUSION: The data suggest that PROGINS is not related either to endometriosis-associated infertility or to idiopathic infertility in the population studied.
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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Endometriosis Infertility, Female Polymorphism, Genetic Receptors, Progesterone Adult Case-Control Studies Endometriosis Endometriosis Female Gene Frequency Gene Frequency Genetic Predisposition to Disease Genotype Humans Infertility, Female Polymerase Chain Reaction Polymorphism, Genetic Prospective Studies Receptors, Progesterone

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