Inhibition of steroid sulfatase activity in endometriotic implants by STX64 (667Coumate): a potential new therapy

L. Fusi, Luca Fusi, Fusi L, Purohit A, A. Purohit, Jan J. Brosens, J Brosens, Woo LW, L. W. Lawrence Woo, L W L Woo, Potter BV, B. V. L. POTTER, M J Reed, Michael Reed, Reed MJ
TheScientificWorldJournal · 2008 · vol. 8 , pp. 1325–1327 · doi:10.1100/tsw.2008.164 · PMID:19112542 · PMC5849069 · W2125898668
Other OA: gold CC0 ⤵ 3 in-corpus citations
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-08 ⓘ

This study investigated the inhibition of steroid sulfatase activity in endometriotic implants using STX64 (667Coumate), proposing it as a potential new therapy for endometriosis.

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Abstract

Endometriosis is a common and debilitating condition of women in their reproductive age that is associated with pain and infertility. Current medical treatments are only partially effective and associated with wide-ranging side effects. New understanding of local estrogen production by endometriotic tissue and the availability of powerful suppressing drugs may herald a new era in the treatment of this condition.

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Condition tags

endometriosisinfertility

MeSH descriptors

Coumarins Endometriosis Enzyme Inhibitors Steryl-Sulfatase Steryl-Sulfatase Sulfonamides Sulfonic Acids Adult Adult Coumarins Coumarins Coumarins Disease Progression Disease Progression Endometriosis Endometriosis Enzyme Inhibitors Enzyme Inhibitors Estrogens Estrogens

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (11)

Cited by (3)

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