The Medium-Chain Free Fatty Acid Receptor GPR84 in Endometriosis Associated Pain.

Frank Sacher, Fernando O. Martínez, Thomas M. Zollner, Oliver M. Fischer, Manman Guo, Cemsel Bafligil, Stephanie G. Dakin, Jens Nagel, Krina T. Zondervan, Christian Becker, Udo Opermann
2018 · vol. 25 · W2890839991
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⚙ AI-generated summary by claude@2026-06, 2026-06-10 ⓘ

The study investigated the medium-chain free fatty acid receptor GPR84, finding it is expressed on pro-inflammatory macrophages and its pharmacological inhibition reduces inflammatory markers in endometriosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 · read from full text ⓘ

The paper investigates the medium-chain free fatty acid receptor GPR84, focusing on its role in endometriosis-associated pain and inflammatory signaling. It reports that GPR84 is expressed on pro-inflammatory macrophages, can be activated by saturated medium-chain free fatty acids, and that pharmacological inhibition reduces inflammatory markers. The main limitation is that the material provided is a conference/meeting abstract with limited methodological detail available here. This paper is centrally about endometriosis — it specifically examines GPR84 as a mediator of endometriosis-associated inflammatory pain.

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Abstract

The G-protein coupled receptor GPR84 binds and becomes activated by saturated medium-chain free fatty acids, is expressed on pro-inflammatory macrophages and pharmacological inhibition leads to reduction of inflammatory markers.
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Conference item The medium-chain free fatty acid receptor GPR84 in endometriosis associated pain - Abstract: - The G-protein coupled receptor GPR84 binds and becomes activated by saturated medium-chain free fatty acids, is expressed on pro-inflammatory macrophages and pharmacological inhibition leads to reduction of inflammatory markers. - Publication status: - Published - Peer review status: - Peer reviewed Actions Access Document - Files: - - (Preview, Accepted manuscript, pdf, 83.4KB, Terms of use) - - Publisher copy: - 10.1177/1933719118759999 Authors - Publisher: - SAGE Publications - Host title: - 65th Annual Meeting of the Society for Reproductive Investigation (SRI 2018) - Journal: - 65th Annual Meeting of the Society for Reproductive Investigation (SRI 2018) More from this journal - Publication date: - 2018-02-28 - Acceptance date: - 2017-12-27 - DOI: - ISSN: - 1933-7191, 1933-7205 - Pubs id: - pubs:846640 - UUID: - uuid:64b3ffe7-910f-4ab2-9f0f-b4ef4b52654e - Local pid: - pubs:846640 - Source identifiers: - 846640 - Deposit date: - 2018-06-16 - ARK identifier: Terms of use - Copyright holder: - Society for Reproductive Investigation - Copyright date: - 2018 - Notes: - Copyright © 2018 by Society for Reproductive Investigation. This is the accepted manuscript version of the article. The final version is available online from SAGE Publications at: https://doi.org/10.1177/1933719118759999 If you are the owner of this record, you can report an update to it here: Report update to this record

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endometriosis

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