Expression of metalloproteinase-9 in ectopic endometrium in women with endometriosis.
article
OA: closed
CC0
⤵ 14 in-corpus citations
Abstract
OBJECTIVE: To study the expression of matrix metalloproteinase-9 (MMP-9) in ectopic and eutopic endometrium from women with endometriosis, thereby to determine the role of matrix metalloproteinases in the pathogenesis of endometriosis. METHODS: Both ectopic and eutopic endometrium tissue specimens were obtained from 30 women with endometriosis, and gelatinase activity in the specimens was detected by zymography and quantitated by Gel Documentation Analysis System. RESULTS: MMP-9 was detected in both eutopic and ectopic endometrium, but the latter contained higher levels of MMP-9 than the former did, and as the endometriosis worsened, MMP-9 expression tended to increase further. CONCLUSION: Endometriotic tissue possesses higher level of gelatinase activity than eutopic endometrium from patients with endometriosis does, and MMP-9 might be of importance for the implantation and invasive growth of endometriotic tissue that may lead to endometriosis.
My notes (saved in your browser only)
Condition tags
MeSH descriptors
Citation neighborhood
Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.
Cited by (14)
- The Effect of Imbalanced Progesterone Receptor-A/-B Ratio on Gelatinase Expressions in Endometriosis 2019
- The bimodal role of matrix metalloproteinases and their inhibitors in etiology and pathogenesis of endometriosis (Review) 2018
- Influência da doxiciclina em endometriose experimentalmente induzida em ratas 2018
- Increased Expression Levels of Metalloprotease, Tissue Inhibitor of Metalloprotease, Metallothionein, and p63 in Ectopic Endometrium: An Animal Experimental Study 2018
- Endometriosis 2015
- The molecular connections between the cannabinoid system and endometriosis 2012
- Endometriosis 2010
- Doxycycline causes regression of endometriotic implants: a rat model 2009
- Association between MMP1 and MMP9 activities and ICAM1 cleavage induced by tumor necrosis factor in stromal cell cultures from eutopic endometria of women with endometriosis 2009
- Expression of an extracellular matrix metalloproteinase inducer (basigin) in the human ovary and ovarian endometriosis 2006
- Nuclear Factor-κB (NF-κB): An Unsuspected Major Culprit in the Pathogenesis of Endometriosis That Is Still at Large? 2006
- Increased expression of matrix metalloproteinase-9 in the eutopic endometrial tissue of women with endometriosis 2006
- Evidence for an increased release of proteolytic activity by the eutopic endometrial tissue in women with endometriosis and for involvement of matrix metalloproteinase-9 2004
- Inhibiting MMP activity prevents the development of endometriosis in the chicken chorioallantoic membrane model 2004
Source provenance
- europepmc
- last seen: 2026-06-04T01:30:01.192114+00:00
- openalex
- last seen: 2026-06-04T00:00:01.174412+00:00
- pubmed
- last seen: 2026-05-13T22:13:01.552487+00:00
License: CC0
· commercial use OK