[Comparative study of HLA-DQA1 and HLA-DRB1 allele in patients with endometriosis and adenomyosis]

Lili Zong, Zong L, Pan D, Dejing Pan, Chen W, Weiming Chen, Wei‐Ming Chen, He Y, Yuanli He, Liu Z, Zehuan Liu, Lin J, Jianghai Lin, Jiang-Hai Lin, Xu A, Anlong Xu
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics · 2002 · vol. 19(1) , pp. 49–51 · PMID:11836687 · W2391909097
Observational OA: closed CC0 ⤵ 7 in-corpus citations
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This study found increased frequencies of HLA-DQA1*0401 and decreased frequencies of HLA-DQA1*0301 alleles in patients with endometriosis and adenomyosis compared to controls.

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Abstract

OBJECTIVE: To make a comparative study of HLA-DQA1 and HLA-DRB1 allele frequencies in the cases of endometriosis and adeonmyosis. METHODS: The allelic types of HLA-DQA1 and HLA-DRB1 were detected by polymerase chain reaction-sequence specific primers (PCR-SSP) technique in 51 cases of endometriosis, 45 cases of adenomyosis, and 44 normal individuals as the control. RESULTS: The frequencies of HLA-DQA1*0401(7.8%, 10.0%) were significantly increased in the endometriosis group and the adenomyosis group (Pc=0.03, Pc=0.01), and the frequencies of HLA-DQA1*0301(8.8%, 5.6%) were significantly decreased in these two groups (Pc=0.00, Pc=0.00).There was no significant difference between the frequencies of HLA-DQA1 and HLA-DRB1 of endometriosis and adenomyosis. CONCLUSION: The results indicate that HLA-DQA1*0301 and *0401 alleles are associated with both endometriosis and adenomyosis, and there is perhaps common mechanism involved in both endometriosis and adenomyosis based on HLA-DQA1 and HLA-DRB1 allele frequencies.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Endometriosis Gene Frequency Gene Frequency HLA-DQ Antigens HLA-DR Antigens Asian People Asian People Asian People Endometriosis Endometriosis Female Female Genetic Predisposition to Disease Genetic Predisposition to Disease Genotype Genotype HLA-DQ alpha-Chains HLA-DQ alpha-Chains HLA-DQ Antigens HLA-DQ Antigens

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