Induction of Endometriosis and Adenomyosis by Transvaginal Pituitary Transplantation in Mice with and without Natural Killer Cell Activity

TSUNEMARO KOUJYO, T Koujyo, Shigetsugu Hatakeyama, S Hatakeyama, Hideto Yamada, H Yamada, Kazuya Iwabuchi, K Iwabuchi, Kiichi Kajino, K Kajino, Kazumasa Ogasawara, K Ogasawara, Kazunori Onoé, K Onoe, S Fujimoto, Seiichiro Fujimoto
American journal of reproductive immunology (New York, N.Y. : 1989) · 1998 · vol. 40(6) , pp. 441–446 · doi:10.1111/j.1600-0897.1998.tb00431.x · PMID:9894569 · W1986008418
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Transvaginal pituitary transplantation in mice induced endometriosis and adenomyosis, with reduced natural killer cell activity not appearing necessary for primary development.

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Abstract

PROBLEM: The aims of this study were to establish a mouse model of endometriosis and adenomyosis and to elucidate the necessity of reduced natural killer (NK)-cell and T-cell activities in the establishment of endometriosis and adenomyosis. METHOD OF STUDY: Pituitary glands, submandibular glands, a hypothalami were transvaginally inoculated into the uteri of syngeneic female mice. Twenty weeks later, the recipient mice were sacrificed and examined. RESULTS: Cysts, adhesion of the uteri to surrounding tissues, and adenomyosis had formed in the uteri of 7 (29.2%), 14 (58.3%), and 22 (91.7%) mice, respectively, out of 24 BALB/c mice after the transplantation of pituitary glands. Similar findings were obtained by experiments with C3H/He and C57BL/6 mice. In NK-cell-deficient C57BL/6-bgJ and T-cell-deficient BALB/c nu/nu mice, an increase in the formation of cysts, adhesion, and adenomyosis was not observed. CONCLUSIONS: These findings indicate that transvaginal pituitary transplantation specifically induces cysts, adhesion, and adenomyosis. Reduced NK-cell activities may not be necessary in the primary development of endometriosis and adenomyosis.

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Condition tags

mesh:D004715endometriosisadenomyosis

MeSH descriptors

Disease Models, Animal Endometriosis Endometriosis Endometriosis Killer Cells, Natural Pituitary Gland Uterine Diseases Uterine Diseases Uterine Diseases Animals Female Killer Cells, Natural Mice Mice, Inbred BALB C Mice, Inbred C3H Mice, Inbred C57BL Pituitary Gland T-Lymphocytes T-Lymphocytes Uterus

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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