Deep Endometriosis and Infertility: What Is the Impact of Surgery?

Aris Daniilidis, Angelos Daniilidis, Stefano Angioni, Stefano Di Michele, Konstantinos Dinas, Fani Gkrozou, Maurizio Nicola D’Alterio
Journal of clinical medicine · 2022 · vol. 11(22) , pp. 6727 · doi:10.3390/jcm11226727 · PMID:36431203 · W4309012980
review OA: gold CC0 ⤵ 20 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This review of 23 studies involving 1548 women found that surgery for deep endometriosis may improve pregnancy rates, but further investigation is needed to determine optimal treatment strategies.

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Abstract

In women with deep endometriosis, the spontaneous fertility rate might range from 2 to 10%. The optimal management of these women is still an area of debate. Therefore, this review aims to explore the literature on the impact of deep endometriosis surgery on reproductive outcomes and pregnancy rates in women with and without prior infertility. A total of 392 articles were identified through database searching. Twenty-three studies were eligible to be included in the review. A total of 1548 women were identified, 814 of whom became pregnant, with a mean pregnancy rate of 52.6% (95% CI 49.7-63%). Our review suggests that surgery may improve fertility outcomes. Due to the variability in the studies, it is impossible to stratify fertility outcomes of surgery by the localization of deep endometriosis. More investigations are needed to determine whether surgical management should be first-intention or limited to the failure of medically assisted reproduction treatment.

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Condition tags

endometriosisinfertility

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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