The Serum Levels of the Soluble Factors sCD40L and CXCL1 Are Not Indicative of Endometriosis

Petra Pateisky, Dietmar Pils, Lorenz Kuessel, Ladislaus Szabo, Katharina Walch, Reinhard Obwegeser, R. Obwegeser, René Wenzl, Iveta Yotova
BioMed research international · 2016 · vol. 2016 , pp. 1–8 · doi:10.1155/2016/2857161 · PMID:27190986 · W2338413473
article OA: hybrid CC0 ⤵ 6 in-corpus citations
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This study found no significant differences in serum sCD40L and CXCL1 levels between women with and without endometriosis, indicating they are not suitable noninvasive diagnostic biomarkers.

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Abstract

Endometriosis is a benign but troublesome gynecological condition, characterized by endometrial-like tissue outside the uterine cavity. Lately, the discovery and validation of noninvasive diagnostic biomarkers for endometriosis is one of the main priorities in the field. As the disease elicits a chronic inflammatory reaction, we focused our interest on two factors well known to be involved in inflammation and neoplastic processes, namely, soluble CD40 Ligand and CXCL1, and asked whether differences in the serum levels of sCD40L and CXCL1 in endometriosis patients versus controls can serve as noninvasive disease markers. A total of n = 60 women were included in the study, 31 endometriosis patients and 29 controls, and the serum levels of sCD40L and CXCL1 were measured by enzyme-linked immunosorbent assay. Overall, there were no statistically significant differences in the levels of expression of both sCD40L and CXCL1 between patients and controls. This study adds useful clinical data showing that the serum levels of the soluble factors sCD40L and CXCL1 are not associated with endometriosis and are not suitable as biomarkers for disease diagnosis. However, we found a trend toward lower levels of sCD40L in the deep infiltrating endometriosis subgroup making it a potentially interesting target worth further investigation.

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Condition tags

mesh:D004715endometriosisdie_deep_infiltrating

MeSH descriptors

CD40 Ligand Chemokine CXCL1 Endometriosis Adult Body Mass Index Case-Control Studies CD40 Ligand Chemokine CXCL1 Endometriosis Female Humans Menstrual Cycle Pain Measurement Solubility

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noordeloos 2009062 human human human noordeloos 2009062

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