Additional file 1 of Gene expression profiles separate endometriosis lesion subtypes and indicate a sensitivity of endometrioma to estrogen suppressive treatments through elevated ESR2 expression

Marla, Sushma, Mortlock, Sally, Heinosalo, Taija, Poutanen, Matti, Montgomery, Grant W., McKinnon, Brett David
2024 · doi:10.6084/m9.figshare.26644399.v1 · W6977136771
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Gene expression profiles distinguish endometriosis subtypes and suggest endometriomas are sensitive to estrogen-suppressing treatments due to elevated ESR2 expression.

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Abstract

Additional file 1: Table S1. Hormonal treatment taken by the women within 3 months prior to surgery. Table S2. Top 30 genes (from total of 142 following Bonferroni correction p<3.54x10-06) that were significantly different between proliferative and secretory phases of samples obtained from patient endometrium. Table S3. Genes that were significantly differentially expressed (following Bonferroni correction p<3.41x10-06) between proliferative and medicated samples obtained from patient endometrium. Table S4. Genes that were significantly different (following FDR correction) between secretory and medicated samples obtained from patient endometrium. Table S5. Top 50 genes that were significantly differently expressed (following FDR correction) between DIE and SUP samples. Table S6. Top 50 genes that were significantly differently expressed (following Bonferroni and FDR correction) between OMA and SUP samples. Table S7. Top 50 genes that were significantly differently expressed (following Bonferroni and FDR correction) between OMA and DIE samples. Table S8. Top 100 genes that were significantly (nominal p<0.05) different between medicated and non-medicated samples in OMA. Table S9. Top 100 genes that were significantly (nominal p<0.05)) different between medicated and non-medicated samples in SUP. Table S10. Top 100 genes that were significantly (nominal p<0.05)) different between medicated and non-medicated samples in DIE.

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Condition tags

endometriosisdie_deep_infiltratingendometrioma

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (43)

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