Estradiol modulation of hepatocyte growth factor by stromal fibroblasts in the female reproductive tract

Kimberly D. Coleman, Coleman KD, Wright JA, Jacqueline A. Wright, Ghosh M, Mimi Ghosh, Charles R. Wira, Wira CR, Fahey JV, John V. Fahey
Fertility and sterility · 2009 · vol. 92(3) , pp. 1107–1109 · doi:10.1016/j.fertnstert.2008.10.047 · PMID:19423096 · PMC4322385 · W2009830841
Lab / animal OA: closed CC0 ⤵ 1 in-corpus citation
📄 Open PDF View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-10 ⓘ

Estradiol influences stromal fibroblasts in the female reproductive tract to modulate hepatocyte growth factor, affecting tissue growth and repair.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Primary human uterine, cervical, and ectocervical stromal fibroblasts constitutively secrete hepatocyte growth factor (HGF), yet only uterine stromal fibroblasts increase HGF secretion in response to estradiol. Estradiol-induced HGF secretion by uterine stromal fibroblasts may have a significant effect on uterine cancer and endometriosis.

My notes (saved in your browser only)

MeSH descriptors

Cervix Uteri Estradiol Fibroblasts Hepatocyte Growth Factor Stromal Cells Uterus Adult Adult Aged Aged Cell Communication Cell Communication Cell Communication Cell Proliferation Cell Proliferation Cell Proliferation Cells, Cultured Cells, Cultured Cervix Uteri Cervix Uteri

Citation neighborhood (sparse)

Too few in-corpus citations on either side for a chart; here are the lists.

Cites (3)

Cited by (1)

References (36)

Cited by (1)

Source provenance

europepmc
last seen: 2026-10-17T06:09:56.316927+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:06:23.467768+00:00
unpaywall
last seen: 2026-10-09T06:36:44.367587+00:00
License: CC0 · commercial use OK