Regional homogeneity alterations reflect pain and emotional dysregulation in adenomyosis

Wenjiang Wei, Yanying Chen, Kelei Hua, Bin Xia, Rujin Li, Weizhao Lin, Zichao Chen, Wenqing Xiao, Kanghui Yu, Yi Yin, Shoujun Xu, Yunfan Wu
Annals of medicine · 2026 · vol. 58(1) , pp. 2620857 · doi:10.1080/07853890.2026.2620857 · PMID:41614571 · W7126268062
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Abstract

PURPOSE: Adenomyosis (AM) with dysmenorrhea (AMD) is a global public health concern that may involve abnormal brain function and heightened vulnerability to anxiety and depression. This study aimed to investigate static and dynamic regional homogeneity (sReHo and dReHo) alterations in AMD and their associations with clinical symptoms. METHODS: ) were calculated for significant clusters. Partial correlation analyses assessed relationships between regional homogeneity (ReHo) alterations and clinical measures, controlling for medication use, menstrual phase and psychiatric history. RESULTS: < 0.001). CONCLUSIONS: AMD is characterized by altered intrinsic brain activity in pain- and emotion-related regions, supporting a central mechanism underlying chronic pain and affective symptoms. These findings provide neuroimaging evidence for AMD-related brain dysfunction. Longitudinal studies with larger cohorts and hormonal control are warranted to confirm these results and clarify causal relationships.

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Outcome instruments

VAS-pain

Condition tags

mesh:D004412adenomyosisdysmenorrhea

MeSH descriptors

Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Brain Brain

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (58)

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europepmc
last seen: 2026-06-04T01:30:01.192114+00:00
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