Rhein inhibits endometriosis by targeting microRNA-135

Wang Dan, Dan Wang, Zhang En Jing, Jing Zhang, Juan Jiang, Jiang Juan, Yang Yi, Yi Yang, Jiang Yi Ling
Acta biochimica Polonica · 2022 · vol. 69(3) , pp. 593–597 · doi:10.18388/abp.2020_5935 · PMID:36044630 · W4293917966
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Rhein inhibits human endometrial stroma cell proliferation, migration, and invasion in vitro by targeting microRNA-135.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

The provided text does not include the paper’s study content (e.g., background, experimental design, methods, results, or limitations), and only shows journal submission information and editorial names. As a result, no high-level description of the population or methods, no specific findings, and no explicit caveats can be extracted from the supplied excerpt. This paper’s title indicates a focus on using Rhein to inhibit endometriosis by targeting microRNA-135, but the actual supporting data are not present in the provided text. This paper is centrally about endometriosis — Rhein targeting microRNA-135.

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Abstract

Endometriosis is a serious human gynecological disorder of women of reproductive age. The present study was designed to explore the therapeutic implications of rhein in the management of endometriosis. The results showed that rhein significantly (p<0.05) inhibited the proliferation of endometrial stroma cells in a dose-dependent fashion. Besides, the rhein treated endometrial stroma cells showed significantly (p<0.05) lower migration and invasion, in vitro. Transwell and wound healing assays showed that rhein also suppressed the migration and invasion of the endometrial stroma cells. Rhein was shown to target miR-135 at the molecular level to exert its anti-proliferative effects against the human endometrial stroma cells. Conversely, overexpression of miR-135 could nullify the anti-proliferative effects of rhein. Taken together, the findings of the present study highlight the therapeutic utility of rhein against human endometriosis. However, more in vivo studies are required.
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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis MicroRNAs

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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