[Use of ceftriaxone against parametritis after radical surgery for cancer of the uterine cervix]

1. The bacteria isolated from pelvic dead space drainage well reflect the characteristics of prophylactic drugs. As drugs advance from penicillin (PC) to tetracycline (TC) to the first, second and third generation cephems, detection rates for Gram-negative bacilli, mainly Escherichia coli, decrease remarkably, while those for Gram-positive cocci, mainly Enterococcus faecalis, increase. 2. The bacteria isolated from the drainage and those which later caused parametritis and purulent lymphocyst were closely related. It is therefore very important to identify bacteria present in the drainage. 3. Judging from changes occurred in blood levels of ceftriaxone (CTRX) and its effective transfer to the pelvic dead space when CTRX 2 g was administered once daily, this administration regimen is considered to control even parametritis and purulent lymphocyst satisfactorily. 4. CTRX 2 g was administered once daily for 5 consecutive days to each of 4 patients with parametritis, and it was observed that the general efficacy was good in 3 of the 4 cases.