Candida catheter-related bloodstream infection (CRBSI) is a biofilm-related disease, which is usually refractory because antifungals show limited effect. With medical development and increase in number of compromised hosts, CRBSI became mor…
The placental passage and the the therapeutic efficacy of flomoxef (FMOX, 6315-S) were studied in patients in the perinatal period. A summary of the obtained results is as follows: 1. Concentrations of FMOX in maternal serum, umbilical cord…
We determined MIC values of cefpiramide (CPM) against clinical isolates from 100 patients who were subjected to total hysterectomy between April 1986 and March 1988. We also investigated the concentrations of CPM in uterine tissue and asses…
1. The bacteria isolated from pelvic dead space drainage well reflect the characteristics of prophylactic drugs. As drugs advance from penicillin (PC) to tetracycline (TC) to the first, second and third generation cephems, detection rates f…
The purpose of the study was to examine the penetration of cefoperazone (CPZ) into the exudate of retroperitoneal space after (semi-)radical hysterectomy in patients with uterine carcinoma and to evaluate the suitability of its prophylactic…
Cefbuperazone (CBPZ), a new cephamycin antibiotic, was studied for the distribution in the genital organs and the excretion to the pelvic dead space exudate by bioassay, and the following results were obtained. CBPZ was rapidly distributed …
Piperacillin (PIPC) was administered to 4 cases with obstetrical and gynecological infections and the following results were obtained. 1. PIPC was administered by intravenous drip infusion with 4 g per day for 7--14 days. The clinical effic…
Piperacillin (PIPC) was administered to patients with obstetrical and gynecological infectious diseases and we studied its clinical effect and tissue distribution. 1. Clinical results. PIPC was administered to 26 patients at a dose of 2--4 …
Fundamental and clinical studies were made on piperacillin (PIPC) and the results were obtained as follows. Serum and uterine tissue concentrations of PIPC were obtained from 36 to 215 minutes after intravenous single shot of 2 g of PIPC. T…