Methylation Profile of HOXA 11 Gene in Eutopic Endometrium on Endometriosis Patient with Infertility

Muharam Natadisastra, Raden Muharam, Valencia Yuwono, Ririn Rahmala Febri, Asmarinah Asmarinah
In: Indonesian Journal of Obstetrics and Gynecology · 2018 · pp. 110 · doi:10.32771/inajog.v6i2.771 · W2897562901
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This study found significant hypermethylation of the HOXA11 gene in the eutopic endometrium of Indonesian women with endometriosis and infertility compared to fertile controls.

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This cross-sectional study investigated the methylation status of the HOXA11 gene in the eutopic endometrium of infertile patients with histopathologically confirmed endometriosis. The research compared these patients against a control group of fertile individuals without endometriosis, analyzing tissue samples collected from two Indonesian hospitals over a one-year period. Results indicated statistically significant hypermethylation of the HOXA11 gene in the endometriosis group, which the authors suggest may explain poor endometrial receptivity and offers potential avenues for epigenetic therapies. This paper is centrally about endometriosis — specifically examining epigenetic modifications associated with infertility in affected patients.

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Abstract

Objective: To investigate the HOXA11 gene profile on endometriosispatients with infertility in Indonesia.Methods: This cross sectional study was conducted in Dr. CiptoMangunkusumo Hospital from July 2015- June 2016. The subjectswere endometriosis patients with infertility who have beenconfirmed histopathological. The control group was taken fromnon-endometriosis and fertile patients. Eutopic endometriumsamples were taken and examined for the methylation of HOXA 11gene.Results: Both groups consist of six patients. The difference ofmethylation of HOXA 11 gene between those two groups isstatistically significant (p=0.03). There was hyper methylation inendometriosis group.Conclusion: There is a hyper methylation of HOXA 11 gene ineutopic endometrium of endometriosis patients with infertility.Thus, possibly can explain the poor endometrial receptivityin endometriosis patient and give a broad research area inepigenetic therapy of endometriosis.[Indones J Obstet Gynecol 2018; 6-2: 110-113]Keywords: endometriosis, epigenetic, HOXA 11, infertility,methylation
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Objective

To investigate the HOXA11 gene profile on endometriosis patients with infertility in Indonesia.

Methods

This cross sectional study was conducted in Dr. Cipto Mangunkusumo Hospital from July 2015- June 2016. The subjects were endometriosis patients with infertility who have been confirmed histopathological. The control group was taken from non-endometriosis and fertile patients. Eutopic endometrium samples were taken and examined for the methylation of HOXA 11 gene.

Results

Both groups consist of six patients. The difference of methylation of HOXA 11 gene between those two groups is statistically significant (p=0.03). There was hyper methylation in endometriosis group.

Conclusion

There is a hyper methylation of HOXA 11 gene in eutopic endometrium of endometriosis patients with infertility. Thus, possibly can explain the poor endometrial receptivity in endometriosis patient and give a broad research area in epigenetic therapy of endometriosis. [Indones J Obstet Gynecol 2018; 6-2: 110-113]

Keywords

endometriosis, epigenetic, HOXA 11, infertility, methylation

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Condition tags

endometriosisinfertility

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References (16)

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