{"paper_id":"8acaf71d-1461-4304-a462-a4aa38a2872d","body_text":"Methylation Profile of HOXA 11 Gene in Eutopic Endometrium on Endometriosis Patient with Infertility\nDOI:\nhttps://doi.org/10.32771/inajog.v6i2.771Abstract\nObjective: To investigate the HOXA11 gene profile on endometriosis\npatients with infertility in Indonesia.\nMethods: This cross sectional study was conducted in Dr. Cipto\nMangunkusumo Hospital from July 2015- June 2016. The subjects\nwere endometriosis patients with infertility who have been\nconfirmed histopathological. The control group was taken from\nnon-endometriosis and fertile patients. Eutopic endometrium\nsamples were taken and examined for the methylation of HOXA 11\ngene.\nResults: Both groups consist of six patients. The difference of\nmethylation of HOXA 11 gene between those two groups is\nstatistically significant (p=0.03). There was hyper methylation in\nendometriosis group.\nConclusion: There is a hyper methylation of HOXA 11 gene in\neutopic endometrium of endometriosis patients with infertility.\nThus, possibly can explain the poor endometrial receptivity\nin endometriosis patient and give a broad research area in\nepigenetic therapy of endometriosis.\n[Indones J Obstet Gynecol 2018; 6-2: 110-113]\nKeywords: endometriosis, epigenetic, HOXA 11, infertility,\nmethylation","source_license":"CC0","license_restricted":false}