CLINICAL FEATURES AND LABORATORY CHARACTERISTICS OF PATIENTS WITH OVARIAN ENDOMETRIOMA AND INFERTILITY DEPENDING ON THE TYPE OF PRECONCEPTION PREPARATION

Approximately 30-40% of all forms of endometriosis consist of endometriotic ovarian cysts, which directly affect the ovarian reserve of women by mechanical impact on healthy tissues and foci of local inflammatory processes and oxidative stress.The aim of the study was to evaluate the impact of preconception antioxidant and vitamin therapy in combination with sclerotherapy of ovarian endometrioma on hormonal profile indicators and serum tumor markers in women with endometriosis-associated infertility.Materials and Methods. In a prospective clinical study, changes in hormonal profile indicators and serum tumor markers depending on the type of preconception preparation of women with endometriosis-associated infertility before IVF cycle were evaluated. 110 women were divided into 3 clinical groups.Results and Discussion. Significant differences between groups were found depending on the preparation for the IVF cycle. In both the first clinical group, where only sclerotherapy was performed, and the second group, where women received preconception preparation in combination with sclerotherapy, a decrease in basal FSH levels by 1.2 and 1.5 times, respectively, was established. This decrease in FSH levels contributed to the normalization of the LH to FSH ratio, whereas in the comparison group, the FSH level remained almost unchanged and the LH/FSH ratio remained low. There was a tendency towards relatively stable levels of anti-Müllerian hormone in serum, indicating the safety of the sclerotherapy method and its gentle impact on ovarian reserve. A more pronounced decrease in serum CA 125 tumor rmarker levels was observed in the second clinical group (by 1.95 times), somewhat less in the first group (by 1.6 times), while in the comparison group, the indicator remained relatively stable.Conclusions. The use of sclerotherapy of ovarian endometrioma in combination with preconception antioxidant and vitamin therapy before the IVF cycle positively affects the main parameters of hormonal profile and serum tumor markers in patients with endometriosis-associated infertility.