HIF-1α regulates DcR3 to promote the development of endometriosis

Jianhua Guan, Xuhong Huang, Ziyang Zhou, Shaojing Li, Fengmian Wang, Yu‐Hong Han, Yuhong Han, Nuo Yin
European journal of obstetrics, gynecology, and reproductive biology · 2024 · vol. 296 , pp. 185–193 · doi:10.1016/j.ejogrb.2024.02.035 · PMID:38458034 · W4391999326
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This study found that HIF-1α regulates DcR3 expression in ectopic endometrium, which is upregulated in endometriosis and promotes disease progression by enhancing cell migration and adhesion under hypoxic conditions.

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Abstract

OBJECTIVE: The aim of this study was to investigate the expression and clinical significance of HIF-1α and DcR3 in endometriosis by analysing clinical case data. Tissue samples were collected for tissue chip analysis and staining, and human endometrial stromal cells were isolated and cultured for cell experiments. Additionally, experiments were conducted on collected peritoneal fluid to explore the association and role of HIF-1α and DcR3 in endometriosis. STUDY DESIGN: Patients who visited the Department of Obstetrics and Gynaecology at Central Hospital in Fengxian District, Shanghai, from January 2018 to December 2021 were recruited for this controlled study. Clinical data and tissue chip staining results were collected for multiple regression analysis on the clinical significance of HIF-1α and DcR3. Endometrial tissue, ovarian cysts, and pelvic fluid were collected, and human endometrial stromal cells were cultured. The impact of HIF-1α on DcR3 in different oxygen environments and its role in endometriosis were investigated through PCR, Western blotting, enzyme-linked immunosorbent assay, as well as adhesion and migration assays. RESULTS: In patients with endometriosis, the expression of DcR3 and HIF-1α was found to be upregulated and correlated in ectopic endometrium. The expression of DcR3 served as an indicator of the severity of endometriosis. Hypoxia induced the expression of DcR3, which was regulated by HIF-1α and promoted migration and adhesion. CONCLUSION: DcR3 can be used as a clinical indicator to assess the severity of endometriosis. The hypoxic environment in endometriosis enhances disease progression by regulating DcR3 through HIF-1α.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Hypoxia-Inducible Factor 1, alpha Subunit Hypoxia-Inducible Factor 1, alpha Subunit Hypoxia-Inducible Factor 1, alpha Subunit Hypoxia-Inducible Factor 1, alpha Subunit Hypoxia-Inducible Factor 1, alpha Subunit Receptors, Tumor Necrosis Factor, Member 6b Receptors, Tumor Necrosis Factor, Member 6b Receptors, Tumor Necrosis Factor, Member 6b Receptors, Tumor Necrosis Factor, Member 6b Receptors, Tumor Necrosis Factor, Member 6b Endometrium Endometrium Endometrium Endometrium Endometrium

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