[The action of p38 MAP kinase and its inhibitors on endometriosis].

Wei-Dong Zhou, Weidong Zhou, Qiong-Hua Chen, Qionghua Chen, Qing-Xi Chen, Qing‐Xi Chen
Yao xue xue bao = Acta pharmaceutica Sinica · 2010 · vol. 45(5) , pp. 548–54 · PMID:20931753 · W2279354077
article OA: closed CC0 ⤵ 7 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This paper explores the role of p38 MAP kinase in endometriosis pathogenesis, highlighting its activation by sex hormones and inflammation and the potential of p38 MAPK inhibitors as a novel therapeutic strategy.

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Abstract

Endometriosis, an oestrogen-dependent disorder, is related to inflammation, p38 Mitogen activated protein kinases (p38 MAPK) can be activated by sex hormone and inflammatory factors, which plays an important role in many cellular reactions such as apoptosis, proliferation, inflammation and stresses, etc. Many studies showed that p38 MAPK was participated directly in regulating the pathogenesis of endometriosis. The special regulatory action of p38 MAPK on sex hormone and inflammation may help us to understand the intricate endometriosis pathological hypothesis. p38 MAPK inhibitors play a key role in the the study of endometriosis, and show great promise for the future. Blocking and regulating the expression of p38 MAPK on the signal transduction pathway level may hope to be a new strategy to prevent and treat endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis p38 Mitogen-Activated Protein Kinases p38 Mitogen-Activated Protein Kinases Animals Anti-Inflammatory Agents, Non-Steroidal Anti-Inflammatory Agents, Non-Steroidal Anti-Inflammatory Agents, Non-Steroidal Endometriosis Endometriosis Enzyme Inhibitors Enzyme Inhibitors Enzyme Inhibitors Female Humans Imidazoles Imidazoles Inflammation Inflammation Inflammation p38 Mitogen-Activated Protein Kinases

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (30)

Cited by (7)

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