Spontaneous cutaneous umbilical endometriosis: Report of a new case with immunohistochemical study and literature review

article OA: green CC0 ⤵ 60 in-corpus citations
AI-generated summary by claude@2026-06, 2026-06-08

This paper reports a case of spontaneous umbilical endometriosis, a rare condition where endometrial tissue grows on the skin, and reviews its clinical and pathological characteristics.

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Abstract

Endometriosis (i.e., the presence of functional endometrial tissue outside the uterine cavity) may rarely affect the skin either spontaneously or secondary to abdomino-pelvic surgery. Spontaneous cutaneous endometriosis appears most commonly on the umbilicus (Villar nodule) and manifests with a red-brown nodule that characteristically shows cyclic variations (tenderness or bleeding) with the menstrual cycle. We present herein a new case of spontaneous cutaneous endometriosis of the umbilicus that was studied immunohistochemically and review the salient clinicopathologic features of this rare condition.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Skin Diseases Umbilicus Adult Endometriosis Endometriosis Female Humans Immunohistochemistry Keratin-7 Keratin-7 Receptors, Estrogen Receptors, Estrogen Receptors, Progesterone Receptors, Progesterone Skin Diseases Skin Diseases Umbilicus

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Cited by (50)

Source provenance

europepmc
last seen: 2026-06-04T01:30:01.192114+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-05-13T22:16:35.898691+00:00
License: CC0 · commercial use OK