Immunohistochemical localization of granulocyte-macrophage colony-stimulating factor in matched endometriosis and endometrial tissues

Sharpe-Timms KL, Kathy L. Sharpe-Timms, K L Sharpe-Timms, Bruno PL, P L Bruno, Patrick L. Bruno, Penney LL, L L Penney, John T. Bickbel, Bickel JT, J T Bickel
American journal of obstetrics and gynecology · 1994 · vol. 171(3) , pp. 740–745 · doi:10.1016/0002-9378(94)90091-4 · PMID:8092224 · W1988386780
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This study used immunohistochemistry to determine the location of granulocyte-macrophage colony-stimulating factor in matched samples of endometriosis and normal endometrial tissue.

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Abstract

OBJECTIVE: Murine endometrial granulocyte-macrophage colony-stimulating factor has been related to macrophage recruitment and activation and postulated to mediate reproductive events. This study was designed to determine whether granulocyte-macrophage colony-stimulating factor is present in normal human endometrium or endometriosis. STUDY DESIGN: Granulocyte-macrophage colony-stimulating factor was immunohistochemically evaluated in matched endometrial and endometriosis biopsy specimens (n = 19) and endometrial biopsy specimens from disease-free patients (n = 8). Staining differences were determined with McNemar's, Fisher's, and Wilcoxon's tests. RESULTS: Granulocyte-macrophage colony-stimulating factor was primarily localized in endometrial and endometriotic epithelial cells. Expression (p = 0.71) and staining intensity (p = 0.37) was similar in matched proliferative-phase endometrium and endometriosis. Matched secretory-phase endometrium and endometriosis also expressed granulocyte-macrophage colony-stimulating factor in similar proportions (p = 0.12), but staining intensity was enhanced in secretory endometriosis compared with secretory endometrium (p = 0.05). Endometrial granulocyte-macrophage colony-stimulating factor did not vary throughout the menstrual cycle, but endometriotic expression (p = 0.013) and staining intensity (p = 0.008) were significantly greater in the secretory phase. CONCLUSIONS: Granulocyte-macrophage colony-stimulating factor is localized in endometrial and endometriotic epithelial cells with increased expression in secretory-phase endometriosis. Granulocyte-macrophage colony-stimulating factor may elicit migration, proliferation, and activation of endometrial and peritoneal macrophages.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Granulocyte-Macrophage Colony-Stimulating Factor Endometriosis Endometriosis Endometrium Endometrium Epithelium Epithelium Epithelium Female Female Granulocyte-Macrophage Colony-Stimulating Factor Granulocyte-Macrophage Colony-Stimulating Factor Humans Humans Immunohistochemistry Immunohistochemistry Menstrual Cycle Menstrual Cycle

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