Increased Expression of Pattern Recognition Receptors and Nitric Oxide Synthase in Patients with Endometriosis

Seung Geun Yeo, Yong Sung Won, Ho Yun Lee, Young Il Kim, Young‐Il Kim, Jin-Woo Lee, Dong Choon Park
International journal of medical sciences · 2013 · vol. 10(9) , pp. 1199–1208 · doi:10.7150/ijms.5169 · PMID:23935397 · W2137139724
article OA: gold CC0 ⤵ 22 in-corpus citations
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Abstract

OBJECTIVE: Endometriosis is characterized by repeated inflammatory changes and serious adhesions, inducing innate and adaptive immune responses within the abdominal cavity. To assess these immune responses, we evaluated the levels of expression of Toll-like receptors (TLR)-1, -2, -4, -5, and -9; nucleotide-binding oligomerization domains (NOD)-1 and -2; interleukins-1β, -6, -8, -10, and -12; interferon-γ; tumor necrosis factor-α; inducible nitric oxide synthase (iNOS) and endothelial NOS (eNOS); and immunoglobulins (Igs) in patients with endometriosis. METHODS: The levels of TLRs, NODs, cytokines, and NOS mRNAs in peritoneal effusions were assessed by real time reverse transcription-polymerase chain reaction; and IgG, IgA and IgM concentrations were measured by enzyme-linked immunosorbent assays (ELISA) in 40 patients with and 40 without endometriosis. Findings from the two groups were compared. RESULTS: We observed expression of all pattern recognition receptors (PRRs), cytokines, and NOS mRNAs and Igs in the effusion fluid of patients with and without endometriosis. The levels of TLR-2 and -9; NOD-1 and -2; iNOS and eNOS mRNAs and CA 125 were significantly higher in the endometriosis than in the non-endometriosis group (p<0.05 each). Moreover, PRR, cytokine, and NOS expression showed significant correlations (p<0.05). CONCLUSIONS: PRRs, cytokines, and NOS, which act cooperatively in the innate immune response, are closely associated with endometriosis. Increased expression of TLR-2, TLR -9, NOD-1, NOD-2, and NOS mRNA in peritoneal fluid may be associated with endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis Nitric Oxide Synthase Receptors, Pattern Recognition Adult Endometriosis Enzyme-Linked Immunosorbent Assay Female Humans Interleukin-10 Interleukin-10 Interleukin-12 Interleukin-12 Interleukin-1beta Interleukin-1beta Interleukin-6 Interleukin-6 Interleukin-8 Interleukin-8 In Vitro Techniques

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