Affected sib-pair analysis in endometriosis

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AI-generated summary by claude@2026-06, 2026-06-07

This paper reviews genetic evidence for endometriosis and outlines the affected-sib pair analysis approach used in the OXEGENE study to identify disease susceptibility genes.

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Abstract

This paper (i) reviews the current clinical and molecular genetic data which strongly suggest that endometriosis has a genetic basis; (ii) outlines the general principles of affected-sib pair analysis; and (iii) describes the Oxford Endometriosis Gene (OXEGENE) Study which aims, using a positional cloning approach, to identify susceptibility genes involved in the development of the disease.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Adult Chromosome Mapping Endometriosis Female Genetic Predisposition to Disease Glutathione Transferase Glutathione Transferase Humans Multifactorial Inheritance Multifactorial Inheritance Nuclear Family Pedigree UDPglucose-Hexose-1-Phosphate Uridylyltransferase UDPglucose-Hexose-1-Phosphate Uridylyltransferase

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

Cited by (38)

Source provenance

europepmc
last seen: 2026-06-04T01:30:01.192114+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-05-13T22:13:19.284922+00:00
License: CC0 · commercial use OK