The effects of genistein as antiinflammatory and antiangiogenesis in primary endometriosis cell culture

Sutrisno Sutrisno, Mariyani Mariyani, Ita Herawati, Evi Rinata, Jehanara Jehanara, Yuyun Yueniwati, Nurdiana Nurdiana, Noorhamdani Noorhamdani, Sanarto Santoso
In: Asian Pacific Journal of Reproduction · 2014 · vol. 3(4) , pp. 299–304 · doi:10.1016/s2305-0500(14)60043-9 · W2069642810
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Genistein treatment of primary endometriosis cells reduced levels of IL-1β, TNF-α, IL-6, VEGF-A, and MMP-2 in a dose- and time-dependent manner compared to controls.

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Abstract

To investigate whether genistein is anti-inflammation and anti-angiogenesis in endometriosis cells. Primary endometriosis cells were divided into seven groups, including control group and genistein-treatment group at dose 5 until 50 μmol/L. The times of incubation is 6, 24, and 48 hours. Levels of TNF-α, IL-6, IL-1β, MMP-2, and VEGF-A in supernatant cells were determined using the enzyme linked immunosorbent assay. The level of IL-1β was significantly lower in genistein-treatment at dose 20 until 50 μM compared to the control group (6 hours of treatment) (P<0.05). In 24 hours of treatment, the level of IL-1β was significantly lower in genistein-treatment start at all doses compared to control group (P <0.05). For 48 hours of incubation, the level of IL-1β was significantly lower in of genistein-treatment group at dose 10 until 50 μM than that to control group (P<0.05). The level of TNF-α and IL-6 were significantly decreased in genistein-treatment compared to control group in all duration of treatment (P<0.05). Level of VEGF-A were significantly lower in genistein-treatment at dose 20 until 50 μM compared to control group (P<0.05). The level of MMP-2 was significantly lower in the genistein-treatment at dose 10 and 30 μM compared to control group in 6 hours of treatment (P<0.05), at dose 10, 40, and 50 μM (24 hours of treatment), and all doses (48 hours of treatment). In conclusion, genistein act as anti-inflammatory and anti-angiogenesis in primary culture cells of endometriosis.

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endometriosis

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