Tumor necrosis factor-alpha but not interleukin-1 beta or interleukin-8 concentrations correlate with angiogenic activity of peritoneal fluid from patients with minimal to mild endometriosis

Maas JW, J W Maas, Jacques W.M. Maas, C Calhaz-Jorge, Carlos Calhaz–Jorge, G ter Riet, Gerben ter Riet, Gerard A.J. Dunselman, Dunselman GA, G A Dunselman, A F de Goeij, Anton F.P.M. de Goeij, de Goeij AF, H A Struijker-Boudier, Harry A.J. Struijker-Boudier, Struijker-Boudier HA
Fertility and sterility · 2001 · vol. 75(1) , pp. 180–185 · doi:10.1016/s0015-0282(00)01656-3 · PMID:11163835 · W2058769784
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The study found that tumor necrosis factor-α concentration in peritoneal fluid correlated with angiogenic activity in patients with minimal to mild endometriosis, unlike interleukin-1β or interleukin-8.

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Abstract

OBJECTIVE: To assess the angiogenic activity of peritoneal fluid in women with minimal to mild endometriosis and to investigate the relationship between this activity and the concentration of macrophage-derived angiogenic factors and clinical variables, such as phase of menstrual cycle, type of lesion, and revised American Society for Reproductive Medicine classification. DESIGN: In vivo bioassay. SETTING: Tertiary-care university medical center. PATIENT(S): Fifty-two female volunteers with laparoscopic findings indicating minimal to mild endometriosis. INTERVENTION(S): Peritoneal fluid was collected at the start of laparoscopy. A standard amount of peritoneal fluid was applied to a chick embryo chorioallantoic membrane assay. MAIN OUTCOME MEASURE(S): Angiogenic response was assessed by determining the vascular density index. RESULT(S): 85% of the peritoneal fluid samples induced angiogenesis in the chick embryo chorioallantoic membrane bioassay. Tumor necrosis factor-alpha and total protein were significantly related to the vascular density index, whereas interleukin-1beta, interleukin-8, and clinical variables appeared to not affect the angiogenic response. CONCLUSION(S): The results confirms previous findings of peritoneal fluid angiogenic activity in women with minimal to mild endometriosis and indicate involvement of tumor necrosis factor-alpha.

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Condition tags

endometriosis

MeSH descriptors

Ascitic Fluid Ascitic Fluid Endometriosis Interleukin-1 Interleukin-8 Neovascularization, Pathologic Tumor Necrosis Factor-alpha Adult Adult Allantoin Allantoin Allantoin Animals Animals Chick Embryo Chick Embryo Chorion Chorion Chorion Endometriosis

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