Expression of HOXA10 Gene in Women with Endometriosis: A Systematic Review

Nurunnajah Lazim, Marjanu Hikmah Elias, Zulazmi Sutaji, Abdul Kadir Abdul Karim, Abdul Karim, Muhammad Azrai Abu, Azizah Ugusman, Saiful Effendi Syafruddin, Mohd Helmy Mokhtar, Mohd Faizal Ahmad
International journal of molecular sciences · 2023 · vol. 24(16) , pp. 12869 · doi:10.3390/ijms241612869 · PMID:37629050 · W4385966860
review OA: gold CC0 ⤵ 15 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This systematic review of ten studies found that HOXA10 gene expression is generally downregulated in women with endometriosis, though lesion location can influence this, and measuring it may aid in predicting the condition and fertility.

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Abstract

The homeobox A10 (HOXA10) gene is known to be related to endometriosis; however, due to a lack of knowledge/evidence in the pathogenesis of endometriosis, the mechanisms that link HOXA10 to endometriosis still need to be clarified. This review addresses the difference in the expression of the HOXA10 gene in endometriotic women versus non-endometriotic women across populations by country and discusses its influences on women’s fertility. An organized search of electronic databases was conducted in Scopus, ScienceDirect, PubMed, and Web of Science. The keywords used were (HOXA10 OR “homeobox A10” OR PL OR HOX1 OR HOX1H OR HOX1.8) AND (“gene expression”) AND (endometriosis). The initial search resulted in 623 articles, 10 of which were included in this review. All ten papers included in this study were rated fair in terms of the quality of the studies conducted. The expression of the HOXA10 gene was found to be downregulated in most studies. However, one study provided evidence of the downregulation and upregulation of HOXA10 gene expression due to the localization of endometriotic lesions. Measuring the expression of the HOXA10 gene in women is clinically essential to predicting endometriosis, endometrial receptivity, and the development of pinopodes in the endometrium during the luteal phase.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Benzeneacetamides Benzeneacetamides Benzeneacetamides Benzeneacetamides Benzeneacetamides Benzeneacetamides Benzeneacetamides Benzeneacetamides Benzeneacetamides Benzeneacetamides Benzeneacetamides Benzeneacetamides Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (91)

Cited by (15)

Source provenance

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