Medical therapy for recurring catamenial pneumothorax following pleurodesis

Ronald L. Dotson, R L Dotson, Matthew C. Peterson, C M Peterson, Raymond C. Doucette, R C Doucette, R Quinton, Ronald Quinton, D Y Rawson, Daniel Y. Rawson, Kirtly Parker Jones, K P Jones
Obstetrics and gynecology · 1993 · vol. 82(4) , pp. 656–658 · doi:10.1097/00006250-199310000-00038 · PMID:8378002 · W2071593770
article OA: closed CC0 ⤵ 11 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Leuprolide acetate followed by norethindrone successfully resolved recurring postsurgical catamenial pneumothorax for one year, but recurrence was associated with vaginal bleeding despite hormonal suppression.

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Abstract

BACKGROUND: Catamenial pneumothorax, a rare complication of systemic endometriosis, has been difficult to treat successfully. Successful medical therapy is associated with amenorrhea. CASE: A 44-year-old white woman with recurring catamenial pneumothorax underwent thoracotomy and abrasive pleurodesis. Following the procedures, pneumothorax occurred again and she was treated with the GnRH analogue leuprolide acetate, 3.75 mg monthly intramuscularly. After 6 months, her therapy was changed to continuous hormonal suppression with norethindrone, 0.7 mg/day. After 6 months of this therapy and into the third episode of vaginal bleeding, the patient had another recurrent pneumothorax. CONCLUSION: Leuprolide acetate followed by continuous hormonal suppression with norethindrone was successful for 1 year in resolving recurring postsurgical catamenial pneumothorax, but the problem recurred with the resumption of vaginal bleeding during progestin therapy. Successful medical therapy requires amenorrhea.

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Condition tags

endometriosis

MeSH descriptors

Leuprolide Menstruation Pleura Pneumothorax Adult Female Humans Leuprolide Pleura Pneumothorax Pneumothorax Recurrence

Citation neighborhood

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