Expression of Aromatase Cytochrome P450 in Eutopic Endometrium and Its Application as a Diagnostic Test for Endometriosis

J Kitawaki, Jo Kitawaki, I Kusuki, Izumi Kusuki, Hisato Koshiba, H Koshiba, K Tsukamoto, Katsumi Tsukamoto, H Honjo, Hideo Honjo
Gynecologic and obstetric investigation · 1999 · vol. 48(Suppl. 1) , pp. 21–28 · doi:10.1159/000052865 · PMID:10559661 · W2066763496
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Aromatase cytochrome P450 is expressed in the eutopic endometria of women with endometriosis, allowing its detection in endometrial biopsies to diagnose the condition.

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Abstract

Endometriotic implants, like other estrogen-dependent tumors, contain both estrogen receptors and aromatase cytochrome P450 (P450arom), suggesting that at a local level, endometriotic implants produce estrogens, which may be involved in tissue growth through interaction with the estrogen receptors. P450arom is also expressed in the eutopic endometria of patients with endometriosis, adenomyosis, and/or leiomyomas, whereas neither P450arom protein nor mRNA is expressed in the eutopic endometria of normal menstruating women with cervical carcinoma in situ yet showing no other gynecological disease (disease-free). Examination of P450arom expression in endometrial biopsy specimens enables the physician to discriminate between the presence and absence of endometriosis, and may be used as an initial screening at outpatient infertility clinics. Copyrightz1999S.KargerAG,Basel

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Condition tags

mesh:D004715endometriosisadenomyosisinfertility

MeSH descriptors

Aromatase Endometriosis Endometrium Gene Expression Regulation, Enzymologic Adult Aromatase Aromatase Aromatase Biopsy Blotting, Southern Endometriosis Endometriosis Endometrium Endometrium Female Humans Immunohistochemistry Predictive Value of Tests Reverse Transcriptase Polymerase Chain Reaction Sensitivity and Specificity

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (27)

Cited by (24)

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