Circulating and peritoneal fluid interleukin-6 levels and gene expression in pelvic endometriosis

Vânia Teixeira De Andrade, Andréa Prestes Nácul, Betânia Rodrigues dos Santos, Sheila Bünecker Lecke, Poli Mara Spritzer, Débora Martinho Morsch
Experimental and therapeutic medicine · 2017 · vol. 14(3) , pp. 2317–2322 · doi:10.3892/etm.2017.4794 · PMID:28962161 · W2735587418
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

Peritoneal fluid IL-6 levels were significantly higher in women with endometriosis, correlating with disease severity, but IL-6 gene expression in adipose or endometrial tissue did not differ between groups.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 · read from full text ⓘ

This case-control study measured interleukin-6 (IL-6) concentrations in serum and peritoneal fluid (PF) and assessed IL-6 gene expression by reverse transcription-quantitative PCR in adipose tissue and endometrial samples from 30 women with pelvic endometriosis and 18 controls with a normal pelvis. PF IL-6 was higher in endometriosis patients than controls, and stage III/IV disease had higher PF IL-6 than stage I/II and control groups; PF IL-6 also correlated strongly with endometriosis severity (r=0.77). IL-6 gene expression did not differ significantly between groups in endometrial samples or adipose tissue, and the authors suggest the increased PF IL-6 is not specifically attributable to regional adipose tissue. This paper is centrally about endometriosis — it evaluates circulating/peritoneal IL-6 levels and related gene expression to link IL-6 to presence and severity of pelvic endometriosis.

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Abstract

Current data are inconsistent regarding the association between interleukin-6 (IL-6), a marker of acute phase inflammation, and pelvic endometriosis. The aim of the present study was to assess IL-6 levels in serum and peritoneal fluid (PF), as well as IL-6 gene expression in adipose tissue (AT) and endometrial samples in pelvic endometriosis. A total of 30 patients with endometriosis and 18 women with a normal pelvis were enrolled in this case-control study. IL-6 levels in PF and serum were determined using a human enzyme-linked immunosorbent assay and IL-6 gene expression was evaluated using reverse transcription-quantitative polymerase chain reaction. It was observed that IL-6 levels in the PF were higher in patients with endometriosis than in the control group (P=0.047) and patients with stage III/IV endometriosis exhibited higher IL-6 levels in the PF than those with stage I/II endometriosis and the control group (P<0.001). Furthermore, a strong correlation between PF IL-6 levels and the revised American Society for Reproductive Medicine score for endometriosis severity was identified (r=0.77; P<0.001). IL-6 gene expression did not differ significantly between endometriosis and control groups in endometrial samples or in AT of both groups. The results of the current study suggest that there may be an association between IL-6 and the presence and severity of pelvic endometriosis. The source of this higher IL-6 seems not to be specifically related to regional AT.
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Print ISSN: 1792-0981 Online ISSN: 1792-1015 International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease. International Journal of Oncology is an international journal devoted to oncology research and cancer treatment. Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery. Oncology Reports is an international journal devoted to fundamental and applied research in Oncology. Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine. Oncology Letters is an international journal devoted to Experimental and Clinical Oncology. Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology. International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis. Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology. Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition. Publishes open-access research on using epigenetics to advance understanding and treatment of human disease. An International Open Access Journal Devoted to General Medicine. Article - Authors: - Pages: 2317-2322|Published online on: July 13, 2017https://doi.org/10.3892/etm.2017.4794 - Expand metrics + Current data are inconsistent regarding the association between interleukin‑6 (IL‑6), a marker of acute phase inflammation, and pelvic endometriosis. The aim of the present study was to assess IL‑6 levels in serum and peritoneal fluid (PF), as well as IL‑6 gene expression in adipose tissue (AT) and endometrial samples in pelvic endometriosis. A total of 30 patients with endometriosis and 18 women with a normal pelvis were enrolled in this case‑control study. IL‑6 levels in PF and serum were determined using a human enzyme‑linked immunosorbent assay and IL‑6 gene expression was evaluated using reverse transcription‑quantitative polymerase chain reaction. It was observed that IL‑6 levels in the PF were higher in patients with endometriosis than in the control group (P=0.047) and patients with stage III/IV endometriosis exhibited higher IL‑6 levels in the PF than those with stage I/II endometriosis and the control group (P<0.001). Furthermore, a strong correlation between PF IL‑6 levels and the revised American Society for Reproductive Medicine score for endometriosis severity was identified (r=0.77; P<0.001). IL‑6 gene expression did not differ significantly between endometriosis and control groups in endometrial samples or in AT of both groups. The results of the current study suggest that there may be an association between IL‑6 and the presence and severity of pelvic endometriosis. The source of this higher IL‑6 seems not to be specifically related to regional AT. Copy and paste a formatted citation Spandidos Publications style De Andrade VT, Nácul AP, Dos Santos BR, Lecke SB, Spritzer P and Morsch DM: Circulating and peritoneal fluid interleukin‑6 levels and gene expression in pelvic endometriosis. Exp Ther Med 14: 2317-2322, 2017. APA De Andrade, V.T., Nácul, A.P., Dos Santos, B.R., Lecke, S.B., Spritzer, P., & Morsch, D.M. (2017). Circulating and peritoneal fluid interleukin‑6 levels and gene expression in pelvic endometriosis. Experimental and Therapeutic Medicine, 14, 2317-2322. https://doi.org/10.3892/etm.2017.4794 MLA De Andrade, V. T., Nácul, A. P., Dos Santos, B. R., Lecke, S. B., Spritzer, P., Morsch, D. M."Circulating and peritoneal fluid interleukin‑6 levels and gene expression in pelvic endometriosis". Experimental and Therapeutic Medicine 14.3 (2017): 2317-2322. Chicago De Andrade, V. T., Nácul, A. P., Dos Santos, B. R., Lecke, S. B., Spritzer, P., Morsch, D. M."Circulating and peritoneal fluid interleukin‑6 levels and gene expression in pelvic endometriosis". Experimental and Therapeutic Medicine 14, no. 3 (2017): 2317-2322. https://doi.org/10.3892/etm.2017.4794

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