Endometriosis‐Associated Infertility: Double Intrauterine Insemination Improves Fecundity in Patients Positive for Antiendometrial Antibodies

Michael Subit, Pickens Gantt, Pickens A. Gantt, Mike Broce, Dara Seybold, Dara J Seybold, Gary W. Randall, Gary Randall
American journal of reproductive immunology (New York, N.Y. : 1989) · 2011 · vol. 66(2) , pp. 100–107 · doi:10.1111/j.1600-0897.2010.00973.x · PMID:21244562 · W1600720746
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This study found that double intrauterine insemination improved fecundity in women with endometriosis-associated infertility who were positive for antiendometrial antibodies.

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Abstract

Citation Subit M, Gantt P, Broce M, Seybold DJ, Randall G. Endometriosis‐associated infertility: double intrauterine insemination improves fecundity in patients positive for antiendometrial antibodies. Am J Reprod Immunol 2011; 66: 100–107 Problem Prospective registry study evaluating effects of endometriosis (E) and serum antiendometrial antibodies (AEA) on fecundity in intrauterine insemination (IUI) cycles. Method of study AEA assays on 572 consecutive women receiving 969 single and 274 double IUI cycles. Logistic regression was utilized. Results Fecundity was 11.5% (143/1243 cycles). Double IUI improved fecundity with significance achieved in certain study groups. Compared to the AEA− subgroup, all study groups except for the E+ AEA− group had significantly lower fecundity. Two study groups receiving double IUI had significantly increased fecundity, E− AEA+ (OR: 5.1, CI: 1.1–22.7, P = 0.032) and E+ AEA+ (OR: 4.1, CI: 1.2–14.0, P = 0.025) and significant predictors of pregnancy (E− AEA+, OR: 7.8, CI: 1.7–36.2, P = 0.009 and E+ AEA+, OR: 4.2, CI: 1.2–15.1, P = 0.026). Conclusion Double IUI improves fecundity in AEA+ patients. E‐associated infertility is better diagnosed by the AEA assay than by surgery. Double IUI should be attempted prior to assisted reproductive technologies in AEA+ patients with normal fallopian tubes.

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Autoantibodies Endometriosis Endometrium Fertility Infertility, Female Insemination, Artificial Adult Autoantibodies Autoimmune Diseases Autoimmune Diseases Endometriosis Endometriosis Endometrium Female Fertility Humans Infertility, Female Infertility, Female Insemination, Artificial Logistic Models

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