Endometriosis: Serum-soluble CD23 in patients with endometriosis and the effect of treatment with danazol and leuprolide acetate depot injection*

O A Odukoya, Amolak S. Bansal, A Bansal, A P Wilson, Anne P. Wilson, Anthony P. Weetman, A P Weetman, Ian Cooke, I D Cooke
Human Reproduction · 1995 · vol. 10(4) , pp. 942–946 · doi:10.1093/oxfordjournals.humrep.a136067 · PMID:7650148 · W2281959447
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Abstract

Activated B cells have recently been shown to produce soluble CD23 from their membranes. The serum-soluble CD23 concentration in 21 patients with pelvic pain diagnosed as having endometriosis and confirmed by histology, and in 18 patients without pelvic pain, who had a normal pelvis during laparoscopic sterilization, was studied by chemiluminescent enzyme-linked immunosorbent assay. The endometriosis patients were randomized to 3 months of either danazol or leuprolide acetate injection. Serum was taken before and after 3 months of therapy. The serum-soluble CD23 concentration was significantly elevated in patients with endometriosis when compared with the controls (P 0.05). The serum concentration of soluble CD23 decreased significantly on treatment with danazol but not leuprolide acetate (P < 0.05). We conclude that the elevation of soluble CD23 in patients with endometriosis suggests that there is activation of B cells, which respond to danazol but not leuprolide acetate injection.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Danazol Endometriosis Leuprolide Receptors, IgE B-Lymphocytes B-Lymphocytes Danazol Delayed-Action Preparations Endometriosis Endometriosis Female Humans Leuprolide Lymphocyte Activation Receptors, IgE

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