In vitro model of stromal and epithelial immortalized endometriotic cells

Mariarosaria Boccellino, Lucio Quagliuolo, Annarita Verde, Raffaele La Porta, Stefania Crispi, Maria Teresa Piccolo, Antonio Vitiello, Alfonso Baldi, Pietro Giulio Signorile, Pietro G. Signorile
Journal of cellular biochemistry · 2011 · vol. 113(4) , pp. 1292–1301 · doi:10.1002/jcb.24000 · PMID:22109698 · W2059105605
article OA: bronze CC0 ⤵ 14 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Researchers established immortalized human endometriotic stromal and epithelial cell lines retaining natural endometrial characteristics for use as an experimental model of endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Endometriosis is a relatively common chronic gynecologic disorder that usually presents with chronic pelvic pain or infertility. It results from implantation of endometrial tissue outside the uterine cavity. Despite its frequency and its impact on quality of life, the understanding of pathogenesis of endometriosis remains incomplete and its treatment remains controversial. In this work, we established a suitable in vitro model system of immortalized human endometriotic cell line taking advantage of the human telomerase reverse transcriptase. The results demonstrate that these cells retain the natural characteristics of endometrial cells in term of phenotype and of functional expression of estrogen and progesterone receptors, without chromosomal abnormalities. In conclusion, these cells are potentially useful as an experimental model to investigate endometriosis biology.

My notes (saved in your browser only)

Condition tags

mesh:D004715endometriosischronic_pelvic_paininfertility

MeSH descriptors

Endometriosis Stromal Cells Base Sequence Cell Line, Transformed DNA Primers Endometriosis Epithelial Cells Epithelial Cells Female Humans Immunohistochemistry In Vitro Techniques Karyotyping Reverse Transcriptase Polymerase Chain Reaction Stromal Cells

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (29)

Cited by (14)

Source provenance

europepmc
last seen: 2026-06-04T01:30:01.192114+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-05-13T22:16:29.858026+00:00
License: CC0 · commercial use OK