The Exosomal Long Noncoding RNA aHIF is Upregulated in Serum From Patients With Endometriosis and Promotes Angiogenesis in Endometriosis

Junjun Qiu, Jun-Jun Qiu, Xiaojing Lin, Xiao-Jing Lin, Tingting Zheng, Ting-Ting Zheng, Xiao-Yan Tang, Xiaoyan Tang, Ying Zhang, Keqin Hua, Ke-Qin Hua
Reproductive sciences (Thousand Oaks, Calif.) · 2019 · vol. 26(12) , pp. 1590–1602 · doi:10.1177/1933719119831775 · PMID:30808247 · W2917526184
article OA: closed CC0 ⤵ 44 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

Serum exosomal long noncoding RNA aHIF is elevated in endometriosis patients and promotes angiogenesis by activating VEGF-A, VEGF-D, and bFGF.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

The study investigated the distribution and expression of the long noncoding RNA antisense hypoxia-inducible factor (aHIF) across ectopic, eutopic, and normal endometria, and tested whether aHIF carried in serum exosomes is altered in endometriosis. Serum exosomal aHIF levels were measured in patients with endometriosis and compared with aHIF expression in matched ectopic endometria, and endometriotic cyst stromal cells (ECSCs)-derived exosomes were characterized for uptake by human umbilical vein endothelial cells (HUVECs); in vitro assays assessed how exosomal aHIF affects angiogenesis-related signaling. aHIF was highly expressed in ectopic endometria, serum exosomal aHIF was upregulated and correlated with ectopic aHIF, and exosomal transfer of aHIF from ECSCs to HUVECs promoted proangiogenic behavior via activation of VEGF-A, VEGF-D, and basic fibroblast growth factor. The paper’s mechanistic work is based on cell-based assays rather than in vivo validation, and it does not report a limitation about causality beyond its experimental model. This paper is centrally about endometriosis — it links exosomal lncRNA aHIF upregulation in patient serum to exosome-mediated promotion of angiogenesis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Exosomes Neovascularization, Pathologic RNA, Long Noncoding Up-Regulation Adult Cell Communication Cell Communication Endometriosis Endometriosis Endometriosis Endometrium Endometrium Exosomes Female Fibroblast Growth Factor 2 Fibroblast Growth Factor 2 Humans Human Umbilical Vein Endothelial Cells Human Umbilical Vein Endothelial Cells

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